Acid sphingomyelinase (SMPD1) Mouse Monoclonal Antibody [Clone ID: OTI3H7]
SKU
CF803659
Carrier-free (BSA/glycerol-free) SMPD1 mouse monoclonal antibody, clone OTI3H7 (formerly 3H7)
$620.00
3 Days*
Specifications
| Product Data | |
| Clone Name | OTI3H7 |
|---|---|
| Application | IHC, Simple Western, WB |
| Recommended Dilution | WB 1:2000, IHC 1:150 ; Simple Western 1:20-1:50 |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 62-341 of human SMPD1 (NP_000534) produced in E.coli. |
| Buffer | Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose) |
| Reconstitution Method | For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific) |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Ambient |
| Gene Name | sphingomyelin phosphodiesterase 1 |
| Database Link | |
| Background | The protein encoded by this gene is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. The encoded protein also has phospholipase C activity. Defects in this gene are a cause of Niemann-Pick disease type A (NPA) and Niemann-Pick disease type B (NPB). Multiple transcript variants encoding different isoforms have been identified. provided by RefSeq, Jul 2010 |
| Synonyms | ASM; ASMASE; NPD |
| Reference Data | |
| Protein Categories | Intracellular Proteins, Secreated Proteins |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | Lysosome, Metabolic pathways, Sphingolipid metabolism |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other "OTI3H7" antibodies (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| TA803659 | SMPD1 mouse monoclonal antibody, clone OTI3H7 (formerly 3H7) | 100 ul |
$447.00
|
|
| TA803659AM | SMPD1 mouse monoclonal antibody, clone OTI3H7 (formerly 3H7), Biotinylated | 100 ul |
$509.00
|
|
| TA803659BM | SMPD1 mouse monoclonal antibody, clone OTI3H7 (formerly 3H7), HRP conjugated | 100 ul |
$509.00
|
|
| TA803659S | SMPD1 mouse monoclonal antibody, clone OTI3H7 (formerly 3H7) | 30 ul |
$200.00
|
|
Citations
Human glaucoma is associated with sphingomyelin depletion and acid sphingomyelinase elevation in retinal ganglion cells
Seidel, Patel, Warden et al
Scientific Reports (2026)
Seidel, Patel, Warden et al
Scientific Reports (2026)
AI Summary: In this study, the OriGene anti-ASM (SMPD1, TA803659) antibody was used to assess acid sphingomyelinase protein expression in retinal ganglion cells, helping to reveal its elevation in glaucomatous human retinas.
Snippet: Novus Biologicals, Centennial, CO), ASM (a.k.a., SMPD1, 1:200, TA803659, Origene, Rockville, MD), NSM (a.k.a., SMPD3, 1:200, PA5-49140, Thermo Fisher Scientific, Detroit, MI), sphingomyelin synthase 1 (SMS1, 1:200, AB247063, Abcam, United Kingdom), sphingomyelin synthase 2 (SMS2, 1:200, NBP1-92436, Novus Biologicals, Centennial, CO)
Showing 1-1 of 1 papers.
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complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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