BRCA1 Mouse Monoclonal Antibody [Clone ID: OTI5D10]
SKU
CF802618
Carrier-free (BSA/glycerol-free) BRCA1 mouse monoclonal antibody, clone OTI5D10 (formerly 5D10)
$620.00
3 Days*
Specifications
| Product Data | |
| Clone Name | OTI5D10 |
|---|---|
| Application | IHC |
| Recommended Dilution | IHC 1:150 |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1151-1473 of human BRCA1 (NP_009225) produced in E.coli. |
| Buffer | Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose) |
| Reconstitution Method | For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific) |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Ambient |
| Gene Name | BRCA1 DNA repair associated |
| Database Link | |
| Background | This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. provided by RefSeq, May 2009 |
| Synonyms | BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53 |
| Reference Data | |
| Protein Categories | Cancer: Gastrointestinal, Cancer: Gynecologic, Cancer: Sarcoma, Cardiovascular diseases, Growth Factors, Intracellular Proteins |
| Protein Families | Druggable Genome, Transcription Factors |
| Protein Pathways | Ubiquitin mediated proteolysis |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other "OTI5D10" antibodies (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| TA802618 | BRCA1 mouse monoclonal antibody, clone OTI5D10 (formerly 5D10) | 100 ul |
$447.00
|
|
| TA802618AM | BRCA1 mouse monoclonal antibody,clone 5D10, Biotinylated | 100 ul |
$509.00
|
|
| TA802618BM | BRCA1 mouse monoclonal antibody,clone 5D10, HRP conjugated | 100 ul |
$509.00
|
|
| TA802618S | BRCA1 mouse monoclonal antibody, clone OTI5D10 (formerly 5D10) | 30 ul |
$200.00
|
|
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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