CD8A Mouse Monoclonal Antibody [Clone ID: OTI7C10]
SKU
CF802376
Carrier-free (BSA/glycerol-free) CD8A mouse monoclonal antibody, clone OTI7C10 (formerly 7C10)
$620.00
3 Days*
Specifications
| Product Data | |
| Clone Name | OTI7C10 |
|---|---|
| Application | FC, IHC, WB |
| Recommended Dilution | WB 1:2000, IHC 1:150,FLOW 1:100 |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 22-182 of human CD8A (NP_001759) produced in E.coli. |
| Buffer | Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose) |
| Reconstitution Method | For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific) |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Ambient |
| Predicted Protein Size | 23.5 kDa |
| Gene Name | CD8a molecule |
| Database Link | |
| Background | The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Nov 2011 |
| Synonyms | CD8; Leu2; MAL; p32 |
| Note | WB application:Only overexpression results are guaranteed, not endogenous |
| Reference Data | |
| Protein Categories | ADC Targets, CD Markers, Immune system diseases, Intracellular Proteins, Membrane Proteins |
| Protein Families | Adult stem cells, Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein, Transmembrane |
| Protein Pathways | Antigen processing and presentation, Cell adhesion molecules (CAMs), Hematopoietic cell lineage, Primary immunodeficiency, T cell receptor signaling pathway |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other "OTI7C10" antibodies (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| TA802376 | CD8A mouse monoclonal antibody, clone OTI7C10 (formerly 7C10) | 100 ul |
$447.00
|
|
| TA802376AM | CD8A mouse monoclonal antibody,clone 7C10, Biotinylated | 100 ul |
$509.00
|
|
| TA802376BM | CD8A mouse monoclonal antibody,clone 7C10, HRP conjugated | 100 ul |
$509.00
|
|
| TA802376S | CD8A mouse monoclonal antibody, clone OTI7C10 (formerly 7C10) | 30 ul |
$200.00
|
|
Citations
Association Between Intra-Tumoral Immune Response and Programmed Death Ligand 1 (PD-L1) in Gastric Cancer
Yan, Yang, Wang et al
Med. Sci. Monit. (2019) 25, 6916-6921 DOI: 10.12659/MSM.916432
Yan, Yang, Wang et al
Med. Sci. Monit. (2019) 25, 6916-6921 DOI: 10.12659/MSM.916432
AI Summary: OriGene products contributed to this study by providing the CD8 (OTI7C10) and CD4 (OTI1D6) monoclonal antibodies, which were used for immunohistochemical staining to assess tumor-infiltrating lymphocytes in gastric cancer tissues.
Snippet: A total of 8 gastric TMAs was made. PD-L1 (28-8) (Roche Diagnostics, Basel, Switzerland), CD8 (OTI7C10;OriGene Technologies, Inc., Beijing, China) and CD4 (OTI1D6;OriGene Technologies, Inc.) monoclonal antibodies were used to stain the TMAs
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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