UNG Mouse Monoclonal Antibody [Clone ID: OTI2C12]
SKU
CF503563
Carrier-free (BSA/glycerol-free) UNG mouse monoclonal antibody, clone OTI2C12 (formerly 2C12)
$620.00
3 Days*
Specifications
| Product Data | |
| Clone Name | OTI2C12 |
|---|---|
| Application | IF, IHC, WB |
| Recommended Dilution | WB 1:500~2000, IHC 1:150, IF 1:100 |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Mouse |
| Isotype | IgG2b |
| Clonality | Monoclonal |
| Immunogen | Full length human recombinant protein of human UNG(NP_550433) produced in HEK293T cell. |
| Buffer | Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose) |
| Reconstitution Method | For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific) |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Ambient |
| Predicted Protein Size | 34.5 kDa |
| Gene Name | uracil DNA glycosylase |
| Database Link | |
| Background | This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases. provided by RefSeq |
| Synonyms | DGU; HIGM4; HIGM5; UDG; UNG1; UNG2; UNG15 |
| Reference Data | |
| Protein Categories | Immune system diseases, Intracellular Proteins, Membrane Proteins |
| Protein Families | Druggable Genome, Stem cell - Pluripotency |
| Protein Pathways | Base excision repair, Primary immunodeficiency |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other "OTI2C12" antibodies (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| TA503563 | UNG mouse monoclonal antibody, clone OTI2C12 (formerly 2C12) | 100 ul |
$447.00
|
|
| TA503563AM | UNG mouse monoclonal antibody, clone OTI2C12 (formerly 2C12), Biotinylated | 100 ul |
$509.00
|
|
| TA503563BM | UNG mouse monoclonal antibody, clone OTI2C12 (formerly 2C12), HRP conjugated | 100 ul |
$509.00
|
|
| TA503563S | UNG mouse monoclonal antibody, clone OTI2C12 (formerly 2C12) | 30 ul |
$200.00
|
|
Citations
APOBEC3B enhances the efficacy of PARP inhibitors in elimination of ovarian cancer stem cell
Rivera, Liu, Enlund et al
Sci Rep (2026) 16 (1), 5194 DOI: 10.1038/s41598-026-35939-y
Rivera, Liu, Enlund et al
Sci Rep (2026) 16 (1), 5194 DOI: 10.1038/s41598-026-35939-y
The kinetics of uracil-N-glycosylase distribution inside replication foci
Ligasová, Frydrych, Piskláková et al
Sci Rep (2025) 15 (1), 3026 DOI: 10.1038/s41598-024-84408-x
Ligasová, Frydrych, Piskláková et al
Sci Rep (2025) 15 (1), 3026 DOI: 10.1038/s41598-024-84408-x
Cited by 2
AI Summary: In this study, the OriGene anti-UNG antibody (clone OTI2C12, TA503563) was used to detect and analyze the distribution and kinetics of uracil-N-glycosylase in human cell lines during the cell cycle.
Snippet: ntation system (Bio-Rad). After washing, the membrane was blocked in 5% BSA in TBS/T (Tris-buffered saline with 0.1% Tween-20) for 1 h and incubated with primary antibody against UNG (clone OTI2C12, OriGene, TA503563) or CDD (Santa Cruz Biotechnology, sc-365292) in 5% BSA and TBS/T overnight at 4 °C with agitation. Thereafter, the membranes were washed with TBS/T and incubated with peroxidase-l
Cytotoxic mechanisms of pemetrexed and HDAC inhibition in non-small cell lung cancer cells involving ribonucleotides in DNA
Iveland, Hagen, de Sousa et al
Sci Rep (2025) 15 (1), 2082 DOI: 10.1038/s41598-025-86007-w
Iveland, Hagen, de Sousa et al
Sci Rep (2025) 15 (1), 2082 DOI: 10.1038/s41598-025-86007-w
Cited by 5
AI Summary: OriGene’s MAb 2c12 antibody (OriGene TA503563), which recognizes the common catalytic domain of UNG1/2, was used in this study to detect UNG protein levels and assess the role of uracil-DNA glycosylase in the cytotoxic mechanisms of pemetrexed and HDAC inhibition in non-small cell lung cancer cells.
Snippet: PBST, treated with SuperSignal West Femto substrate (Thermo Fisher Scientific) and visualized using the Kodak Image station 4000R. Antibodies and reagents Primary antibodies: MAb 2c12 (0.5 µg/ml) (OriGene TA503563) recognizing the common catalytic domain of UNG1/2, mAb beta-Actin (Abcam Ab8226), pAb p21 (abcam Ab18209), pAb γH2AX (Abcam ab2893), pAb cleaved PARP (Abcam Ab4830). Secondary antib
FAM72A degrades UNG2 through the GID/CTLH complex to promote mutagenic repair during antibody maturation
Barbulescu, Chana, Wong et al
Nat Commun (2024) 15 (1), 7541 DOI: 10.1038/s41467-024-52009-x
Barbulescu, Chana, Wong et al
Nat Commun (2024) 15 (1), 7541 DOI: 10.1038/s41467-024-52009-x
Cited by 23
AI Summary: OriGene’s anti-UNG antibody (OTI2C12) was used in this study to detect human UNG2 protein levels, helping to demonstrate how FAM72A promotes UNG2 degradation during antibody maturation.
Snippet: Aldrich, 474790) treatment, CH12 cells were treated with MG132 (3 h, 20 μM) prior to harvesting the pellet. The following antibodies were used for this study: anti-UNG (Abcam, 245630, for mouse;Origene Technologies, OTI2C12, for human), anti-AID (Invitrogen;39-2500), anti-β-actin (Sigma-Aldrich, A2066), anti-α-Tubulin (Abcam, ab4074), anti-MAEA/EMP (ThermoFisher, PA5-47914), anti-MKLN1 (T
HIV-1 Vpr drives a tissue residency-like phenotype during selective infection of resting memory T cells
Reuschl, Mesner, Shivkumar et al
Cell Rep (2022) 39 (2), 110650 DOI: 10.1016/j.celrep.2022.110650
Reuschl, Mesner, Shivkumar et al
Cell Rep (2022) 39 (2), 110650 DOI: 10.1016/j.celrep.2022.110650
Cited by 28
AI Summary: In this study, the UNG Mouse Monoclonal Antibody (clone: OTI2C12; Cat# TA503563) from OriGene Technologies was used to investigate protein expression relevant to HIV-1 infection and T cell reprogramming.
Snippet: Cell Signaling Technologies Cat# 4322;RRID: AB_10544692 Stat5 (D3N2B) Rabbit mAb Cell Signaling Technologies Cat# 25656;RRID: AB_2798908 UNG Mouse Monoclonal Antibody (clone: OTI2C12) OriGene Technologies Cat# TA503563;RRID: AB_11126624 VPRBP Polyclonal antibody (DCAF1 antibody) Proteintech Cat# 11612-1-AP;RRID: AB_2216933 Anti-Actin antibody Sigma-Aldrich Cat# A206;Stat5 (D3N2B) Rabbit mAb Cell Signaling Technologies Cat# 25656;RRID: AB_2798908 UNG Mouse Monoclonal Antibody (clone: OTI2C12) OriGene Technologies Cat# TA503563;RRID: AB_11126624 VPRBP Polyclonal antibody (DCAF1 antibody) Proteintech Cat# 11612-1-AP;RRID:
Anchored linear oligonucleotides: the effective tool for the real-time measurement of uracil DNA glycosylase activity
Ligasová, Rosenberg, Bocková et al
Open Biol (2021) 11 (10), 210136 DOI: 10.1098/rsob.210136
Ligasová, Rosenberg, Bocková et al
Open Biol (2021) 11 (10), 210136 DOI: 10.1098/rsob.210136
Cited by 5
AI Summary: OriGene's anti-UNG primary antibody (TA503563) was used in this study to detect uracil DNA glycosylase protein levels via immunoblotting, supporting the analysis of enzyme activity in the developed assay.
Snippet: The membrane was blocked in 5% BSA in TBS/T (Tris-buffered saline with 0.1% Tween-20) for 1 h and incubated with primary antibody against UNG (OriGene, TA503563) in 5% BSA and TBS/T overnight at 4C with agitation. Then, the membranes were washed Save;- The membrane was blocked in 5% BSA in TBS/T (Tris-buffered saline with 0.1% Tween-20) for 1 h and incubated with primary antibody against UNG (OriGene, TA503563) in 5% BSA and TBS/T overnight at 4C with agitation. …
Showing 1-6 of 16 papers.
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