DAND5 Mouse Monoclonal Antibody [Clone ID: OTI2H3]
SKU
CF503555
Carrier-free (BSA/glycerol-free) DAND5 mouse monoclonal antibody, clone OTI2H3 (formerly 2H3)
$620.00
3 Days*
Specifications
| Product Data | |
| Clone Name | OTI2H3 |
|---|---|
| Application | FC, IHC, WB |
| Recommended Dilution | WB 1:500~2000, IHC 1:150, FLOW 1:100 |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 23-189 of human DAND5(NP_689867) produced in E.coli. |
| Buffer | Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose) |
| Reconstitution Method | For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific) |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Ambient |
| Predicted Protein Size | 18 kDa |
| Gene Name | DAN domain BMP antagonist family member 5 |
| Database Link | |
| Background | This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to bind Nodal and to inhibit the Nodal signaling pathway which patterns left/right body asymmetry. provided by RefSeq |
| Synonyms | CER2; CERL2; CKTSF1B3; COCO; CRL2; DANTE; GREM3; SP1 |
| Reference Data | |
| Protein Categories | Growth Factors, Secreated Proteins |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other "OTI2H3" antibodies (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| TA503555 | DAND5 mouse monoclonal antibody, clone OTI2H3 (formerly 2H3) | 100 ul |
$447.00
|
|
| TA503555AM | DAND5 mouse monoclonal antibody, clone OTI2H3 (formerly 2H3), Biotinylated | 100 ul |
$509.00
|
|
| TA503555BM | DAND5 mouse monoclonal antibody, clone OTI2H3 (formerly 2H3), HRP conjugated | 100 ul |
$509.00
|
|
| TA503555S | DAND5 mouse monoclonal antibody, clone OTI2H3 (formerly 2H3) | 30 ul |
$200.00
|
|
Citations
Elevated serum DAND5 is associated with metastasis and predicts poor prognosis in colorectal cancer
Miao, Zhang, Sun et al
United European Gastroenterol J (2017) 5 (5), 725-734 DOI: 10.1177/2050640616674838
Miao, Zhang, Sun et al
United European Gastroenterol J (2017) 5 (5), 725-734 DOI: 10.1177/2050640616674838
Cited by 10
AI Summary: OriGene products, specifically the DAND5 shRNA (Cat# TL316619) and DAND5 cDNA (Cat# RC221527), were used to manipulate DAND5 expression in colorectal cancer cell lines to assess its functional role in cell proliferation, migration, and invasion in this study.
The BMP inhibitor DAND5 in serum predicts poor survival in breast cancer
Chi, Yao, Hu et al
Oncotarget (2016) 7 (12), 14951-62 DOI: 10.18632/oncotarget.7498
Chi, Yao, Hu et al
Oncotarget (2016) 7 (12), 14951-62 DOI: 10.18632/oncotarget.7498
Cited by 22
AI Summary: OriGene products, specifically the DAND5 antibody (Cat# TA326619) and DAND5 cDNA clone (Cat# RC213348), were used in this study to detect and analyze DAND5 expression in breast cancer tissues and functional assays, contributing to the finding that serum DAND5 is a potential biomarker predicting poor survival in breast cancer patients.
Elevated serum DAND5 is associated with metastasis and predicts poor prognosis in colorectal cancer
Miao, Zhang, Sun et al
United European Gastroenterology Journal (2016)
Miao, Zhang, Sun et al
United European Gastroenterology Journal (2016)
AI Summary: OriGene contributed to this study by providing the monoclonal anti-DAND5 antibody, which was used to detect DAND5 protein levels in colorectal cancer samples.
Snippet: using enhanced chemiluminescence reagents (Pierce, Rockford, IL, USA).The monoclonal anti-DAND5 (dilution 1:2000) antibody was purchased from Origene(Rockville, MD, USA). The monoclonal anti-E-cadherin (dilution 1 ... Cite SaveSaving
Showing 1-3 of 3 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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