TrkC (NTRK3) Mouse Monoclonal Antibody [Clone ID: OTI4E10]
Specifications
| Product Data | |
| Clone Name | OTI4E10 |
|---|---|
| Application | IF, IHC, WB |
| Recommended Dilution | WB 1:1000 IHC 1:50 IF 1:100 |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Full-length protein expressed in 293T cell transfected with human NTRK3 expression vector |
| Buffer | Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose) |
| Reconstitution Method | For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific) |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Ambient |
| Predicted Protein Size | 94.4 kDa |
| Gene Name | neurotrophic receptor tyrosine kinase 3 |
| Database Link | |
| Background | This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. |
| Synonyms | gp145(trkC); TRKC |
| Reference Data | |
| Protein Categories | Cancer: Brain and CNS, Cancer: Head and Neck, Enzyme: Kinases, Growth Factors, Intracellular Proteins, Membrane Proteins |
| Protein Families | Druggable Genome, Protein Kinase, Transmembrane |
| Protein Pathways | Neurotrophin signaling pathway |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other "OTI4E10" antibodies (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| TA500538 | Anti-NTRK3 (TrkC) mouse monoclonal antibody, clone OTI4E10 (formerly 4E10) | 100 ul |
$447.00
|
|
| TA500538AM | Anti-NTRK3 (TrkC) mouse monoclonal antibody, clone OTI4E10 (formerly 4E10), Biotinylated | 100 ul |
$509.00
|
|
| TA500538BM | Anti-NTRK3 (TrkC) mouse monoclonal antibody, clone OTI4E10 (formerly 4E10), HRP conjugated | 100 ul |
$509.00
|
|
| TA500538S | Anti-NTRK3 (TrkC) mouse monoclonal antibody, clone OTI4E10 (formerly 4E10) | 30 ul |
$200.00
|
|
Citations
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