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VMAT2 (SLC18A2) Mouse Monoclonal Antibody [Clone ID: OTI9E11]

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SKU
CF500506
Carrier-free (BSA/glycerol-free) SLC18A2 mouse monoclonal antibody, clone OTI9E11 (formerly 9E11)
Size:
100 ug
Formulation:
Carrier-free Standard
Conjugation:
Unconjugated
  $620.00
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View other "VMAT2 or NM_003054" antibodies

Specifications
Specifications
Product Data
Clone Name OTI9E11
Application FC, IF, IHC, WB
Recommended Dilution WB 1:2000, IHC 1:50, IF 1:100, FLOW 1:100
Reactivity Human, Mouse, Rat
Antibody Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Full-length protein expressed in 293T cell transfected with human SLC18A2 expression vector .
Buffer Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Ambient
Predicted Protein Size 55.7 kDa
Gene Name solute carrier family 18 member A2
Database Link
Background The vesicular monoamine transporter acts to accumulate cytosolic monoamines into synaptic vesicles, using the proton gradient maintained across the synaptic vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs,including reserpine and tetrabenazine.
Synonyms SVAT; SVMT; VAT2; VMAT2
Reference Data
Protein Categories Membrane Proteins
Protein Families Transmembrane
Protein Pathways Parkinson's disease
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Other "OTI9E11" antibodies (4)
SKU Description Size Price
TA500506 Anti-SLC18A2 (VMAT2) mouse monoclonal antibody, clone OTI9E11 (formerly 9E11) 100 ul
$447.00
TA500506AM Anti-SLC18A2 (VMAT2) mouse monoclonal antibody, clone OTI9E11 (formerly 9E11), Biotinylated 100 ul
$509.00
TA500506BM Anti-SLC18A2 (VMAT2) mouse monoclonal antibody, clone OTI9E11 (formerly 9E11), HRP conjugated 100 ul
$509.00
TA500506S Anti-SLC18A2 (VMAT2) mouse monoclonal antibody, clone OTI9E11 (formerly 9E11) 30 ul
$200.00

file-alt Citations

Norepinephrine transporter and vesicular monoamine transporter 2 tumor expression as a predictor of response to 131 I-MIBG in patients with relapsed/refractory neuroblastoma
Batra, Gikandi, Pawel et al
Pediatr Blood Cancer (2023) 71 (1), e30743 DOI: 10.1002/pbc.30743
Cited by 6
AI Summary: OriGene’s VMAT2 antibody (TA500506) was used for immunohistochemical staining of tumor samples to assess VMAT2 protein expression in the study.
Snippet: Background Prior studies suggest that norepinephrine transporter (NET) and vesicular monoamine transporter 2 (VMAT2) mediate meta‐iodobenzylguanidine (MIBG) Save;NET-17 (Mabtechnologies, NET17-1, 1:1000) and VMAT2 (Origene, TA500506, 1:1000) antibodies were used to stain formalin-fixed paraffin-embedded tissue slides
IHC
Somatostatin receptor 2 in 10 different types of human non-neoplastic gastrointestinal neuroendocrine cells
Watanabe, Fujishima, Unno et al
Pathol Res Pract (2023) 244, 154418 DOI: 10.1016/j.prp.2023.154418
Cited by 5
AI Summary: OriGene’s VMAT2 antibody (TA500506) was used for immunohistochemical analysis to help identify and characterize neuroendocrine cell types in the study of somatostatin receptor 2 (SSTR2) distribution in normal human gastrointestinal tissues.
Snippet: Somatostatin is known to inhibit the secretion of various hormones by acting on endocrine cells through the somatostatin receptor 2 (SSTR2). Immunohistochemical Save;VMAT2 ORIGENE TA500506 Mouse AC (121 °C, 5 min), pH6.0 1:3000 4 °C, overnight Histofine Kit
IHC
Identification of a novel monocytic phenotype in Classic Hodgkin Lymphoma tumor microenvironment
Post, Yuan, Holthoff et al
PLoS ONE (2019) 14 (11), e0224621 DOI: 10.1371/journal.pone.0224621
AI Summary: OriGene contributed to this study by providing two monoclonal antibodies to SR-A (MRS1; clone OTI9ES and clone UMAB246), which were used for immunohistochemical analysis to characterize macrophage phenotypes in classic Hodgkin lymphoma tumor microenvironments.
Snippet: Immunohistochemistry was performed using two monoclonal antibodies to SR-A (MRS1;clone OTI9ES;1:150 and clone UMAB 246;1:600;OriGene), CD68 (Clone KP-1;Roche), CD163 (Clone MRQ-26 Cellmarque), CD14 (Clone EPR3653;Ventana), CD30 (Clone
FigureFigureFigure
IHC
Chronic methylphenidate preferentially alters catecholamine protein targets in the parietal cortex and ventral striatum
Quansah, Zetterström
Neurochem. Int. (2019) 124, 193-199 DOI: 10.1016/j.neuint.2019.01.016
AI Summary: In this study, OriGene's NET antibody was used to measure noradrenaline transporter levels in rat brain tissue, contributing to the analysis of how chronic methylphenidate treatment alters catecholamine protein targets in specific brain regions.
Snippet: with 3% milk in TBST buffer (50 mM Tris;150 mM NaCl;0.05% Tween-20;pH 7.5) and incubated overnight with the indicated primary antibodies at 4 °C. The primary antibodies used included: DAT (1:1000 dilution;Santa Cruz, USA), NET (1:1000 dilution;OriGene, USA
WB
Vesicular monoamine transporter protein expression correlates with clinical features, tumor biology, and MIBG avidity in neuroblastoma: a report from the Children's Oncology Group
Temple, Mendelsohn, Kim et al
Eur. J. Nucl. Med. Mol. Imaging (2015)
Cited by 24
AI Summary: In this study, the OriGene VMAT2 antibody was used for immunohistochemical analysis to assess VMAT2 protein expression in neuroblastoma tumors, enabling the researchers to correlate VMAT2 levels with clinical features and MIBG uptake.
Snippet: Membranes were incubated overnight at 4 °C with primary antibodies [VMAT1 (abcam), VMAT2 (OriGene), hNET (MAb Tech- nologies), MYCN (abcam), MYC (Cell Signaling), and GAPDH (Millipore)], then developed using horseradish peroxidase (HRP)-conjugated ... Cite SaveSaving
IHC WB
Distribution of vesicular monoamine transporter 2 protein in human brain: implications for brain imaging studies
Tong, Boileau, Furukawa et al
J. Cereb. Blood Flow Metab. (2011) 31 (10), 2065-75 DOI: 10.1038/jcbfm.2011.63
Cited by 33
AI Summary: OriGene’s anti-human VMAT2 monoclonal antibody (clone 9E11, cat# TA500506) was used to characterize VMAT2-immunoreactive protein distribution in human brain tissues in this study.
Snippet: Another recently available anti-human VMAT2 monoclonal antibody (clone 9E11, cat# TA500506, OriGene Technologies, Rockville, MD, USA) raised against the recombinant, full-length VMAT2 protein was also used to help characterize the VMAT2-immunoreactive protein
WB
Showing 1-6 of 6 papers.
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