IL6 Mouse Monoclonal Antibody [Clone ID: OTI3G9]
SKU
CF500067
Carrier-free (BSA/glycerol-free) IL-6 mouse monoclonal antibody, clone OTI3G9 (formerly 3G9)
$620.00
3 Days*
Specifications
| Product Data | |
| Clone Name | OTI3G9 |
|---|---|
| Application | IF, IHC, WB |
| Recommended Dilution | WB 1:1000; IHC 1:50; IF 1:100 |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG2a |
| Clonality | Monoclonal |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 29-212 of human IL-6 (NP_000591) produced in E.coli. |
| Buffer | Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose) |
| Reconstitution Method | For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific) |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Ambient |
| Predicted Protein Size | 23.5 kDa |
| Gene Name | interleukin 6 |
| Database Link | |
| Background | This gene encodes a cytokine that functions in inflammation and the maturation of B cells. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. |
| Synonyms | BSF-2; BSF2; CDF; HGF; HSF; IFN-beta-2; IFNB2; IL-6 |
| Reference Data | |
| Protein Categories | Allergies and autoimmune diseases, Chemokines, Cytokines, Growth Factors, Intracellular Proteins, Membrane Proteins, Secreated Proteins |
| Protein Families | Druggable Genome, Secreted Protein |
| Protein Pathways | Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, Graft-versus-host disease, Hematopoietic cell lineage, Hypertrophic cardiomyopathy (HCM), Jak-STAT signaling pathway, NOD-like receptor signaling pathway, Pathways in cancer, Prion diseases, Toll-like receptor signaling pathway |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other "OTI3G9" antibodies (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| TA500067 | IL6 mouse monoclonal antibody, clone OTI3G9 (formerly 3G9) | 100 ul |
$447.00
|
|
| TA500067AM | IL6 mouse monoclonal antibody, clone OTI3G9 (formerly 3G9), Biotinylated | 100 ul |
$509.00
|
|
| TA500067BM | IL6 mouse monoclonal antibody, clone OTI3G9 (formerly 3G9), HRP conjugated | 100 ul |
$509.00
|
|
| TA500067S | IL6 mouse monoclonal antibody, clone OTI3G9 (formerly 3G9) | 30 ul |
$200.00
|
|
Citations
ADSC-EVs Activate Autophagy Via the AKT/FOXO1 Pathway to Inhibit Tendon Fibrosis
Zhang, Liu, Zhang et al
Am J Sports Med (2025) 53 (11), 2618-2632 DOI: 10.1177/03635465251358465
Zhang, Liu, Zhang et al
Am J Sports Med (2025) 53 (11), 2618-2632 DOI: 10.1177/03635465251358465
Cited by 4
AI Summary: In this study, OriGene's anti–IL-6 antibody (TA500067S) was used for immunofluorescence to assess inflammation in tendon tissue sections, contributing to the evaluation of ADSC-EVs' effects on tendon fibrosis and healing.
Snippet: Immunofluorescence was performed by incubating tendon tissue sections with rabbit primary antibodies: anti– IL-6 (monoclonal, 1:100, TA500067S;OriGene) and anti– IL-10 (monoclonal, 1:100, ab33471;Abcam). T
Calcitonin gene-related peptide-modulated macrophage phenotypic alteration regulates angiogenesis in early bone healing
Kong, Gao, Li et al
Int Immunopharmacol (2024) 130, 111766 DOI: 10.1016/j.intimp.2024.111766
Kong, Gao, Li et al
Int Immunopharmacol (2024) 130, 111766 DOI: 10.1016/j.intimp.2024.111766
Cited by 15
AI Summary: OriGene products—specifically the IL-6 antibody (TA500067S) and endomucin (EMCN) antibody (TA312706)—were used for immunostaining to assess cytokine expression and endothelial cell markers, contributing to the analysis of macrophage phenotypes and angiogenesis in this study.
Snippet: ere incubated with primary antibodies against YAP1 (1:500, #66900–1, Proteintech, USA) or IL-6 (1:100, TA500067S, Origene, China) at 4 °C overnight. The HUVECs were incubated with primary antibodies against CD31 (1:100, sc-376764, Santa Cruz, USA) and endomucin (EMCN, 1:100, TA312706, Origene) at 4 °C overnight. …
The inhibition of fibrosis and inflammation in obstructive kidney injury via the miR-122-5p/SOX2 axis using USC-Exos
Li, Lu, Guo et al
Biomater Res (2024)
Li, Lu, Guo et al
Biomater Res (2024)
Cited by 15
AI Summary: OriGene's anti-IL-6 antibody (TA500067S) was used in this study to detect IL-6 protein levels, contributing to the assessment of inflammation in obstructive kidney injury.
The Expression of miR-377-3p in Patients with DKD and the Regulatory Mechanism of miR-377-3p on the Inflammatory Response of HK-2 Cells Through TGF-β
Xing, Lu, Liu et al
Diabetes Metab Syndr Obes (2024) 17, 903-911 DOI: 10.2147/DMSO.S449791
Xing, Lu, Liu et al
Diabetes Metab Syndr Obes (2024) 17, 903-911 DOI: 10.2147/DMSO.S449791
AI Summary: In this study, OriGene products including TGF-β mouse monoclonal antibody (TA506583S), IL-6 mouse monoclonal antibody (TA500067S), and IL-18 rabbit polyclonal antibody (TA324190S) were used to detect key inflammatory proteins by Western blot, enabling the analysis of miR-377-3p’s regulatory effects on inflammation in diabetic kidney disease.
Snippet: re purchased from TIANGEN Company. TGF-β mouse monoclonal antibodies (TA506583S), IL-6 mouse monoclonal antibodies (TA500067S), and IL-18 rabbit polyclonal antibodies (TA324190S) were purchased from ORIGENE, and horseradish peroxidase labeled goat anti-Rabbit IgG and goat anti-mouse IgG were sourced from Servicebio. miR-377-3p mimics and miR-377-3p inhibitors were purchased from Guangzhou Ruibo B
Post-transcriptional regulation of the long non-coding RNA HOTAIRM1 involved in cancer
Monnet
Thesis (2024)
Monnet
Thesis (2024)
Snippet: MAGOH (RefSeq NM_002370) Human Tagged ORF Clone (OriGene, Cat # RC203863). This
α2,6-Sialylation Is Upregulated in Severe COVID-19, Implicating the Complement Cascade
Qin, Kurz, Chen et al
ACS Infect Dis (2022) 8 (11), 2348-2361 DOI: 10.1021/acsinfecdis.2c00421
Qin, Kurz, Chen et al
ACS Infect Dis (2022) 8 (11), 2348-2361 DOI: 10.1021/acsinfecdis.2c00421
Cited by 21
AI Summary: OriGene contributed to this study by providing the unconjugated mouse anti-human interleukin-6 antibody (clone no. OTI3G9, catalog no. TA500067), which was used for immunohistochemistry staining to assess IL-6 levels in COVID-19 patient tissues.
Snippet: h Prolong Gold antifade media. Immunohistochemistry Staining Single and multiplex-chromogenic immunohistochemistry were performed using unconjugated mouse anti-human interleukin-6 (clone no. OTI3G9, Origene, catalog no. TA500067, lot no. VE2990982), unconjugated murine anti-human Vimentin (clone no. V9, Ventana Medical Systems, catalog no. 790-2917, lot no. E04396, RRID:AB-2335925) and unconjugat
Showing 1-6 of 19 papers.
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