Hex (HHEX) Mouse Monoclonal Antibody [Clone ID: OTI4B7]
SKU
CF500025
Carrier-free (BSA/glycerol-free) Hex mouse monoclonal antibody, clone OTI4B7 (formerly 4B7)
$620.00
4 Weeks*
Specifications
| Product Data | |
| Clone Name | OTI4B7 |
|---|---|
| Application | WB |
| Recommended Dilution | WB: 1:500 - 1:1000 |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Recombinant fragment expressed in E.coli corresponding to amino acids 100-270 of human Hex |
| Buffer | Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose) |
| Reconstitution Method | For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific) |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Ambient |
| Predicted Protein Size | 29.8 kDa (experimental 44 kDa) |
| Gene Name | hematopoietically expressed homeobox |
| Database Link | |
| Background | Hex is a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in hematopoietic differentiation. |
| Synonyms | HEX; HMPH; HOX11L-PEN; PRH; PRHX |
| Reference Data | |
| Protein Categories | Diabetes, Growth Factors, Intracellular Proteins, Transciption Factors |
| Protein Families | Druggable Genome, Transcription Factors |
| Protein Pathways | Maturity onset diabetes of the young |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other "OTI4B7" antibodies (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| TA500025 | Anti-Hex (Hex) mouse monoclonal antibody, clone OTI4B7 (formerly 4B7) | 100 ul |
$447.00
|
|
| TA500025AM | Anti-Hex (Hex) mouse monoclonal antibody, clone OTI4B7 (formerly 4B7), Biotinylated | 100 ul |
$509.00
|
|
| TA500025BM | Anti-Hex (Hex) mouse monoclonal antibody, clone OTI4B7 (formerly 4B7), HRP conjugated | 100 ul |
$509.00
|
|
| TA500025S | Anti-Hex (Hex) mouse monoclonal antibody, clone OTI4B7 (formerly 4B7) | 30 ul |
$200.00
|
|
Citations
Blood platelets stimulate cancer extravasation through TGFβ-mediated downregulation of PRH/HHEX
Marcolino, Siddiqui, van den Bosch et al
Oncogenesis (2020) 9 (2), 10 DOI: 10.1038/s41389-020-0189-0
Marcolino, Siddiqui, van den Bosch et al
Oncogenesis (2020) 9 (2), 10 DOI: 10.1038/s41389-020-0189-0
Cited by 33
AI Summary: OriGene's PRH49 and PRH51 shRNA plasmids were used in this study to knock down PRH/HHEX expression in prostate epithelial cells, enabling the investigation of how reduced PRH levels affect cancer cell extravasation and response to platelet-derived TGFβ signaling.
Snippet: PRH expression was knocked down in PNT2-C2 cells by transfecting 5 × 106 cells with 5 µg PRH49 and 5 µg PRH51 shRNA plasmids (Origene) using TransIT prostate transfection reagent (Mirus, Madison, WI, USA). Cells transfected with 10 µg SVC shRNA were used as a control. Cells were selected in media containing 1 µg/ml puromycin added 24 h post transfection and experiments were performed using cells h...
Adenosine Suppresses Cholangiocarcinoma Cell Growth and Invasion in Equilibrative Nucleoside Transporters and Proline-Rich Homeodomain Protein-Dependent Pathway
Lertsuwan, Phoaubon, Tasnawijitwong et al
Int J Mol Sci (2020) 21 (3) DOI: 10.3390/ijms21030814
Lertsuwan, Phoaubon, Tasnawijitwong et al
Int J Mol Sci (2020) 21 (3) DOI: 10.3390/ijms21030814
Cited by 7
AI Summary: OriGene contributed to this study by providing the PRH Hex (HHex) antibody (Clone ID: OTI4B7, TA500025), which was used to detect PRH protein levels in cholangiocarcinoma cells and investigate the role of PRH in adenosine-mediated growth suppression.
Snippet: …Primary antibodies included 1:3000 PRH Hex (HHex) (Clone ID: OTI4B7) (TA500025, Origene, Rockville, MD, USA), 1:3000 Phospho-PRH (in-house product from University of Birmingham and was kindly provided by Padme-Sheela Jayaraman), 1:1500 CK2α (2656, Cell Signaling Technology, Danvers, MA, USA), 1:1500 phospho-NF-κB p65 (Ser536) (13346, Cell
Showing 1-2 of 2 papers.
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complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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