Alpha 1 microglobulin (AMBP) Sheep Polyclonal Antibody
Specifications
| Product Data | |
| Application | ELISA, ID |
|---|---|
| Recommended Dilution | ELISA: 1/500-1/1000. Immunodiffusion. |
| Reactivity | Human |
| Antibody Host | Sheep |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Highly pure human alpha-1-microglobulin, prepared from the urine of patients with chronic renal proteinuria (Molecular Weight 25-30 kD). |
| Specificity | This antibody recognises human alpha-1-microglobulin. No cross-reactivity is observed with urine Albumin, Retinol binding protein or beta-2-Microglobulin. It does NOT react with Rat. |
| Buffer | PBS containing 0.09% Sodium Azide as preservative State: Purified State: Liquid purified Ig fraction |
| Concentration | lot specific |
| Purification | Affinity Chromatography on Protein G |
| Conjugation | Unconjugated |
| Storage | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Gene Name | alpha-1-microglobulin/bikunin precursor |
| Database Link | |
| Background | Alpha(1)microglobulin/bikunin precursor specifically interacts with the ORF3 protein of hepatitis E virus and has a direct role in enhancing alpha(1)microglobulin export from the hepatocyte. Bikunin has a role in downregulating PI3 kinase and suppressing tumor invasiveness and metastasis in ovaran cancer cells. I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (H1, H2 or H3) and one light chain, bikunin. Inter-alpha-inhibitor (I-alpha-I) is composed of H1, H2 and bikunin, inter-alpha-like inhibitor (I-alpha-LI) of H2 and bikunin, and pre-alpha-inhibitor (P-alpha-I) of H3 and bikunin. Interacts with FN1 |
| Synonyms | Alpha-1-microglobulin, HCP, Inter-alpha-trypsin inhibitor light chain, ITI-LC, ITIL, Bikunin, HI-30, EDC1, Trypstatin |
| Reference Data | |
| Protein Categories | Intracellular Proteins, Secreated Proteins |
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