Gastrin (GAST) Guinea Pig Polyclonal Antibody
Specifications
| Product Data | |
| Application | IF, IHC |
|---|---|
| Recommended Dilution | Immunohistochemistry on Frozen Sections: 1:1,000-1:1,500 Immunohistochemistry on Paraffin Embedded Tissues: 1:1,000-1:1,500 (microwave treatment recommended) Immunofluorescence Microscopy. Recommended Positive Control: Formalin-fixed paraffin sections of Rat antrum. Working Dilutions: 1:1,000-1:1,500 using FITC, with overnight incubation at 2-8°C. |
| Reactivity | Human, Rat |
| Antibody Host | Guinea Pig |
| Clonality | Polyclonal |
| Immunogen | Synthetic Human Gastrin I conjugated to BSA |
| Specificity | Gastrin-secreting cells are numerous in the antrum and a few are found in the proximal duodenum. The antibody can be used for the diagnosis of Gastrin-producing tumors which are mainly found in the pancreas and occasionally in the stomach and the duodenum. Absorption with 10-100 µg Gastrin 1-34 and CCK 8 per ml antiserum abolishes the staining. |
| Buffer | State: Serum State: Lyophilized Serum |
| Reconstitution Method | Restore in 100 µl distilled water |
| Conjugation | Unconjugated |
| Storage | Prior to reconstitution store at 2-8°C. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Ambient |
| Gene Name | gastrin |
| Database Link | |
| Background | Gastrin is mainly known by its first described role as a gastric acid-hormone but the protein also has the ability to promote cellular growth. More recently, gastrin has been suggested to induce leukocyte-endothelial cell interactions and to have a pro-inflammatory effect. Gastrin has two biologically active peptide forms, G34 and G17 and they activate two different receptors: the CCK-1 receptor, which has low affinity for gastrin but high affinity for the related hormone cholecystokinin (CCK), and the CCK-2 receptor, which has high affinity for both gastrin and CCK and mediates the acid-secretory as well as the proliferative effects of gastrin. |
| Synonyms | GAST, GAS |
| Reference Data | |
| Protein Categories | Secreated Proteins |
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