SQSTM1 (C-term) Guinea Pig Polyclonal Antibody
Specifications
| Product Data | |
| Application | IHC, WB |
|---|---|
| Recommended Dilution | Western blotting: 1/1000-1/2000 (ECL). Immunohistochemistry on Frozen Sections: 1/100-1/600. Immunohistochemistry on Paraffin Embedded Sections: 1/100-1/600 (microwave pretreatment improves staining). Incubation time: 1h at RT, extended with paraffin material. |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Guinea Pig |
| Clonality | Polyclonal |
| Immunogen | C-terminal domain (20 amino acids: C-NYD IGA ALD TIQ YSK HPP PL) of Human p62 protein, coupled to KLH. |
| Specificity | This antibody reacts with Human 62 kD (p62) protein, present in intracytoplasmic inclusions (e.g. hyaline bodies) of hepatocellular carcinoma. p62 protein (also described as ubiqutin-binding protein; sequestosome 1, SQSTM1) has been found in many tissues and cells, including lymphoid cells, serving probably a common cellular signal transduction mechanism (e.g. ubiquitin-associated degradation and autophagy). The antiserum stains also neurofibrillary tangles in the brain of patients suffering from Alzheimer's disease. |
| Buffer | State: Serum State: Liquid Stabilized Antiserum Preservative: 0.09% Sodium Azide |
| Conjugation | Unconjugated |
| Storage | Store undiluted at 2-8°C. DO NOT FREEZE! |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Gene Name | sequestosome 1 |
| Database Link | |
| Synonyms | Sequestosome-1, EBIAP, ORCA, OSIL, p60, p62 |
| Reference Data | |
| Protein Categories | Intracellular Proteins, Nervous system: Neurodegenerative diseases |
| Protein Families | Druggable Genome, Transcription Factors |
Reviews
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Citations
Astrocytes and retrograde degeneration of nigrostriatal dopaminergic neurons in Parkinson's disease: removing axonal debris
Morales, Puertas-Avendaño, Sanchez et al
Transl Neurodegener (2021) 10 (1), 43 DOI: 10.1186/s40035-021-00262-1
Morales, Puertas-Avendaño, Sanchez et al
Transl Neurodegener (2021) 10 (1), 43 DOI: 10.1186/s40035-021-00262-1
Cited by 28
AI Summary: OriGene’s P62 (SQSTM1) antibody (BP5002) was used in this study to detect and analyze autophagy-related processes during the investigation of dopaminergic axon degeneration and debris removal in Parkinson’s disease models.
Showing 1-1 of 1 papers.
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