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OB Cadherin (CDH11) Mouse Monoclonal Antibody [Clone ID: 16A]

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SKU
BM6020P
OB Cadherin (CDH11) mouse monoclonal antibody, clone 16A, Purified
Size:
100 ug
Conjugation:
Unconjugated
  $695.00
2 Weeks*
Bulk/Customize

View other "CDH11 or NP_001788.2" antibodies

Specifications
Specifications
Product Data
Clone Name 16A
Application IF, IHC, WB
Recommended Dilution Immunoblotting.
Immunocytochemistry.
Immunohistochemistry on Frozen Sections: Use a PBS buffer containing 0.1 mM CaCl2 and 0.1 mM MgCl2.
Recommended Dilutions: 1/25-1/50 for Immunohistochemistry with Avidin-biotinylated Horseradish Peroxidase Complex (ABC) as detection reagent and 1/25-1/250 for Immunoblotting applications.
Reactivity Human, Rat
Antibody Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Affinity purified extracellular domain of Human Cadherin-11-GST fusion protein.
Specificity This antibody recognizes the extracellular domain of Cadherin-11.
Buffer PBS with 0.09% Sodium Azide as preservative
State: Purified
State: Liquid purified IgG fraction
Concentration lot specific
Purification Affinity Chromatography
Conjugation Unconjugated
Storage

Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Gene Name cadherin 11
Database Link
Background Cadherins constitute a family of transmembrane glycoproteins involved in Ca2+-dependent cell-cell interactions. The members of this family are differentially expressed in various tissues. They function in the maintenance of tissue integrity and morphogenesis. The cadherins generally contain five extracellular repeats, a transmembrane domain and a cytoplasmic tail that binds to the catenin family of cytoskeletal anchoring proteins which also function as signal transducers. The extracellular domains are responsible for the specificity of homophilic interactions between cells expressing the same cadherin. Cadherins are divided into type I and type II subgroups. Type I cadherins include epithelial cadherin (E-cadherin, cadherin-1 or uvomorulin), neural cadherin (N-cadherin or cadherin-2), placental cadherin (P-cadherin or cadherin-3) and retinal cadherin (R-cadherin or cadherin-4). Kidney cadherin (K-cadherin or cadherin-6) and osteoblast cadherin (OB-cadherin or cadherin-11) are type II cadherins. The progression of carcinomas is associated with the loss of epithelial morphology and a concomitant acquisition of a more mesenchymal phenotype, which is thought to contribute to the invasive and/or metastatic behavior. A putative role for cadherin-11 in these late stages of tumor progression is based on the fact that migration of mesenchymal cells is facilitated when cadherin-11 is highly expressed.
Synonyms Osteoblast cadherin, OSF-4, CDH11, OB Cadherin
Reference Data
Protein Categories Cancer: Brain and CNS, Intracellular Proteins, Membrane Proteins
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Documents
Resources

file-alt Citations

Resistin upregulates chemokine production by fibroblast-like synoviocytes from patients with rheumatoid arthritis
Sato, Muraoka, Kusunoki et al
Arthritis Res Ther (2017) 19 (1), 263 DOI: 10.1186/s13075-017-1472-0
Cited by 67
AI Summary: In this study, OriGene’s CAP1 siRNA (SR321838) and CAP1 antibody (TA326433) were used to investigate the role of CAP1 in resistin-induced chemokine production by fibroblast-like synoviocytes from rheumatoid arthritis patients.
FigureFigureFigure
Abrogation of CC chemokine receptor 9 ameliorates collagen-induced arthritis of mice
Yokoyama, Kohsaka, Kaneko et al
Arthritis Res Ther (2014) 16 (5), 445 DOI: 10.1186/s13075-014-0445-9
Cited by 47
AI Summary: In this study, OriGene products—including the anti-CCR9 antibody (Cat# TA326178) and anti-CCL25 antibody (Cat# TA328184)—were used for immunohistochemistry and Western blotting to detect the expression of CCR9 and CCL25 in synovial tissues, helping to elucidate their roles in rheumatoid arthritis.
FigureFigureFigure
Showing 1-2 of 2 papers.
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