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Desmin Mouse Monoclonal Antibody [Clone ID: RD301]

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SKU
BM6010P
Desmin mouse monoclonal antibody, clone RD301, Purified
Size:
100 ug
Conjugation:
Unconjugated
  $595.00
2 Weeks*
Bulk/Customize

View other "DES" antibodies

Specifications
Specifications
Product Data
Clone Name RD301
Application IF, IHC, WB
Recommended Dilution Western blot.
Immunohistochemistry on Frozen sections.
Immunocytochemistry.
Recommended Dilutions: 1/100-1/200 for Immunohistochemistry with Avidin-Biotinylated Horseradish peroxidase complex (ABC) as detection reagent, and 1/100-1/1000 for Immunoblotting applications.
Reactivity Canine, Chicken, Hamster, Human, Mouse, Porcine, Rabbit, Rat, Zebrafish
Antibody Host Mouse
Isotype IgG2b
Clonality Monoclonal
Immunogen Cytoskeletal desmin extract of chicken gizzard
Specificity RD301 reacts exclusively with Desmin, which is expressed in smooth and striated muscle cells and their tumors e.g. rhabdomyosarcoma and leiomyosarcoma.
Buffer PBS with 0.09% Sodium Azide as preservative
State: Purified
State: Liquid purified IgG fraction
Concentration lot specific
Conjugation Unconjugated
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freeze-thaw cycles.
Stability Shelf life: One year from despatch.
Shipping Blue Ice
Database Link
Background Desmin (53 kDa) exhibits a high degree of tissue specificity, its expression being predominantly confined to all types of muscle cells (cardiac, skeletal and smooth muscle). Regulation of desmin expression is stage and tissue-specific, since it is induced during terminal development of, for example, skeletal muscle cell differentiation. In skeletal en cardiac muscle cells desmin is localized in the Z-disk region and at the intercalated disk. The expression pattern of desmin in smooth muscle is much more heterogenous. Coexpression of vimentin and desmin has been observed in tumors derived from muscle tissue, i.e. rhabdomyosarcomas and leiomyosarcomas. Furthermore, during myocard dysfunction dramatic changes in the distribution of desmin have been observed.
Synonyms DES
Reference Data
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Documents
Resources

file-alt Citations

Cardiac fibroma: A Clinicopathologic Study of a Series of 12 Cases
Teng, Yang, Chen et al
Cardiovasc Pathol (2021) 56, 107381 DOI: 10.1016/j.carpath.2021.107381
Cited by 13
AI Summary: OriGene products contributed to this study by providing the antibodies for immunohistochemical staining—specifically, anti-SMA (clone EP325), anti-S-100 (clone 4C4.9), and anti-Ki-67 (clone EP78)—which were used to characterize the cellular features of cardiac fibroma cases.
Snippet: EP325), S-100 (clone 4C4.9), and Ki-67 (clone EP78). All antibodies were purchased from OriGene Technologies, Inc. (Rockville, MD, USA). For all antibodies, negative and positive controls were routinely performed, including
IHC FISH
Clinicopathological and immunohistochemical features of pulmonary artery sarcoma: A report of three cases and review of the literature
Chen, Zhu, Wang et al
Oncol Lett (2016) 11 (4), 2820-2826 DOI: 10.3892/ol.2016.4308
Cited by 30
AI Summary: OriGene products, specifically anti-CD34 and anti-α-smooth muscle actin antibodies, were used for immunohistochemical analysis to help characterize the tumor cell phenotypes in the diagnosis of pulmonary artery sarcoma in this study.
Showing 1-2 of 2 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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