OriGene Logo

Customer Login

Checkout as a new customer

Creating an account has many benefits:

  • See order and shipping status
  • Track order history
  • Check out faster
Create an Account

Desmoglein 2 (DSG2) Mouse Monoclonal Antibody [Clone ID: G129]

Be the first to review this product
SKU
BM5106
Desmoglein 2 (DSG2) mouse monoclonal antibody, clone G129, Supernatant
Size:
5 ml
Conjugation:
Unconjugated
  $495.00
2 Weeks*
Bulk/Customize

View other "DSG2 or NP_001934.2" antibodies

Specifications
Specifications
Product Data
Clone Name G129
Application ELISA, IHC, WB
Recommended Dilution ELISA.
Western Blot.
Immunohistochemistry on Frozen Sections: Ready-to-use (1 h at RT).
Preincubation with 0.05-0.2% Triton X-100, for 5-10 min, depending on tissue type, is recommended.
Immunohistochemistry on Paraffin Sections: Ready-to-use (overnight at 2-8°C). Enhanced when using the microwave method.
Recommended as Positive Control: CaCo-2, HaCaT.
Reactivity Human
Antibody Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Recombinant peptide (220 aa of 2nd and 3rd extracellular repeat domain).
Specificity This antibody recognizes Desmoglein 2 present in all epithelia and in tumors derived therefrom as well as in heart muscle and dendritic reticulum cells of lymphatic follicles. In basal epithelial cells Desmoglein 2 expression is generally very low.
Reactivities on Cultured Cell Lines: Many, including CaCo-2, HaCaT, MCF-7.
Negative Species: Mouse, Rat.
Buffer State: Supernatant
State: Liquid Cell Culture Supernatant
Preservative: 0.09% Sodium Azide
Conjugation Unconjugated
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Gene Name desmoglein 2
Database Link
Background Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 2 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This second family member is expressed in colon, colon carcinoma, and other simple and stratified epithelial-derived cell lines.
Synonyms DSG2, CDHF5,HDGC
Note Desmoglein 2 (1069 aa; calculated mol. wt. 116,760)
Reference Data
Protein Categories Cardiovascular diseases, Intracellular Proteins, Membrane Proteins
Reviews
Write Review
 
 
 
 
 

Be the first to review this product

Please note:
Only reviews with images are eligible for a $20/20€ Amazon gift card.
Reviews without images are eligible for a $10/10€ Amazon gift card.
For more details about the terms and conditions, please visit the promotion page.

Review image
Documents
Resources

file-alt Citations

Role of Dsg1- and Dsg3-Mediated Signaling in Pemphigus Autoantibody-Induced Loss of Keratinocyte Cohesion
Walter, Vielmuth, Wanuske et al
Front Immunol (2019) 10, 1128 DOI: 10.3389/fimmu.2019.01128
AI Summary: OriGene’s anti-Dsg2 monoclonal antibody was used for immunostaining to detect Dsg2 protein expression in keratinocyte cell lines, contributing to the analysis of desmoglein-mediated signaling in pemphigus-induced loss of cell adhesion.
Snippet: …The following primary antibodies were incubated overnight at 4°C: anti-Dsg3 mAb (clone 5G11, Invitrogen, Carlsbad, CA, USA), anti-Dsg2 mAb (OriGene, Herford, Germany), anti-E-Cadherin mAb (BD Transduction Laboratories, Heidelberg, Germany), anti-PG mAb (Progen, Heidelberg, Germany), anti-DP mAb (NW6, kind gift from Kathleen J. …
FigureFigureFigure
ICC
Interleukin-10 Enhances the Intestinal Epithelial Barrier in the Presence of Corticosteroids through p38 MAPK Activity in Caco-2 Monolayers: A Possible Mechanism for Steroid Responsiveness in Ulcerative Colitis
Lorén, Cabré, Ojanguren et al
PLoS One (2015) 10 (6), e0130921 DOI: 10.1371/journal.pone.0130921
Cited by 56
AI Summary: In this study, OriGene’s anti-Desmoglein-2 antibody (Cat# TA809328) was used to assess desmoglein-2 expression in Caco-2 cell monolayers, contributing to the investigation of how IL-10 and glucocorticoids synergistically enhance intestinal epithelial barrier integrity.
FigureFigureFigure
Showing 1-2 of 2 papers.
Powered by BizGenius
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Related Products