Adgre1 Rat Monoclonal Antibody [Clone ID: BM8]
Specifications
| Product Data | |
| Clone Name | BM8 |
|---|---|
| Application | FC, IF |
| Recommended Dilution | Has been described to work in FACS. Suggested Positive Control: Mouse monocytes. |
| Reactivity | Mouse |
| Antibody Host | Rat |
| Isotype | IgG2a |
| Clonality | Monoclonal |
| Immunogen | Cultured macrophages |
| Specificity | This antibody recognizes the F4/80 antigen on major subpopulations of resident tissue macrophages (Schaller et al. 2002). Antigen Distribution Isolated Cells: The antigen is expressed in vitro on over 80% of M-CSF stimulated bone marrow derived macrophages, after a few days of culture. It is absent from granulocytes, lymphocytes and thrombocytes. Tissue Sections: The antigen is detected on tissue fixed macrophages in all organs tested so far (spleen, lymph nodes, thymus, liver, skin) except lung. It is also present on Langerhans cells in the skin and Kupffer cells in the liver. In complete Freund's adjuvant induced granulomas, the antigen is expressed by inflammatory macrophages, but is absent from epitheloid cells. |
| Buffer | PBS, pH 7.2 Label: FITC State: Liquid purified Ig fraction Stabilizer: 10 mg/ml BSA Preservative: 0.09% Sodium Azide |
| Concentration | 0.1 mg/ml |
| Purification | Affinity Chromatography |
| Conjugation | FITC |
| Storage | Store undiluted at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Gene Name | adhesion G protein-coupled receptor E1 |
| Database Link | |
| Background | The antigen expression increases upon maturation of macrophage precursors in bone marrow and blood as well as in ontogeny. BM8 is the only macrophage marker that is able to distinguish non-destructive from destructive inflammation processes in the pancreas and has been shown to be a unique histological marker of the progression from peri-insulitis to β-cell destruction and diabetes in a mouse diabetes model. |
| Synonyms | Emr1, Gpf480 |
| Reference Data | |
| Protein Categories | GPCR, Intracellular Proteins, Membrane Proteins |
Reviews
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Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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