HIV-2 gp36 Mouse Monoclonal Antibody [Clone ID: BDI411]
$1,005.00
2 Weeks*
Specifications
| Product Data | |
| Clone Name | BDI411 |
|---|---|
| Application | ELISA, IP, WB |
| Recommended Dilution | Suitable for use in Western blot (1/1,000), ELISA (1/500) and Immunoprecipitation. |
| Reactivity | Human Immunodeficiency Virus 2 |
| Antibody Host | Mouse |
| Isotype | IgG2a |
| Clonality | Monoclonal |
| Immunogen | Recombinant gp36, amino acids 390-702 (Art. No. BIN07...) |
| Specificity | This antibody is specific for HIV-2 gp36 antigen. |
| Buffer | 1X PBS, pH 7.2 containing 0.01% Sodium Azide as preservative. State: Purified State: Liquid purified Ig fraction. |
| Concentration | lot specific |
| Purification | Protein G Chromatography. |
| Conjugation | Unconjugated |
| Storage | Store the antibody at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Background | HIV2 infections at present, are predominantly found in west Africa where it is the dominant form of HIV. Both HIV1 and HIV2 have the same modes of transmission and are associated with similar opportunistic infections and AIDS. In persons infected with HIV2, immunodeficiency seems to develop more slowly and to be milder, but as the disease advances, HIV2 infectiousness seems to increase. Little is known about the best approach to the clinical treatment and care of patients infected with HIV2. Some drugs used to treat HIV1 are ineffective. HIV1 and HIV2 have similar gag (viral core) and pol (polymerase) regions, they have relatively dissimilar env (envelope) regions. Owing to this lack of homology in the envelope region, there is little serologic cross-reactivity of the antibodies directed against the envelope antigens of both HIV1 and HIV2. The env gp36 ectodomain is highly conserved and elicits a type-specific antibody response. Hence, most licensed diagnostic assays incorporate gp36-derived antigens to detect HIV2 specific antibodies. It is becoming important to differentiate between single infection with either HIV1 or HIV2 and dual infection. |
| Synonyms | HIV2, Human immunodeficiency virus type 2 |
| Reference Data | |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
Modulation of the NF-κB signaling pathway by the HIV-2 envelope glycoprotein and its incomplete BST-2 antagonism
Dufrasne, Lucchetti, Martin et al
Virology (2017) 513, 11-16 DOI: 10.1016/j.virol.2017.09.024
Dufrasne, Lucchetti, Martin et al
Virology (2017) 513, 11-16 DOI: 10.1016/j.virol.2017.09.024
AI Summary: OriGene's mouse monoclonal anti-HIV-2 gp36 antibody (cat #BM3335) was used in this study to detect HIV-2 Env protein, contributing to the analysis of NF-κB pathway modulation by HIV-2 envelope glycoprotein.
Snippet: … HIVs exploit the transcription factor NF-κB to ensure efficient LTR-driven g.;The membranes were blocked with 5% BSA in TBS containing 0.1% Tween-20 for 1 h, and probed overnight at 4 °C with a rabbit monoclonal anti-BST-2 antibody (Abcam, cat #ab134061, dilution 1:5000) or a mouse monoclonal anti-HIV-2 gp36 antibody (OriGene Europe-Acris antibodies, cat #BM3335, dilution 1:1000)
Showing 1-1 of 1 papers.
Powered by BizGenius
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
Related Products
- Price:
- Actual Price:
Welcome to OriGene AI!
I'm your AI-powered guide to everything OriGene.
Ask me anything:
- Product specs
- Ordering help
- Technical questions
- How to find exactly what your experiment needs
Prefer a live agent? Connect with us by clicking the green chat icon, as seen in the image below or email our team at custsupport@origene.com.
