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IGF1 Receptor (IGF1R) (alpha chain) Mouse Monoclonal Antibody [Clone ID: 1H7]

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SKU
BM2226P
IGF1 Receptor (IGF1R) (alpha chain) mouse monoclonal antibody, clone 1H7, Purified
Size:
200 ug
Conjugation:
Unconjugated
  $645.00
5 Days*
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View other "IGF1R or NP_000866.1" antibodies

Specifications
Specifications
Product Data
Clone Name 1H7
Application FC, IHC, WB
Recommended Dilution Western Blot.
Immunohistochemistry on Paraffin Sections: 1/10-1/40.
Requires Protein digestion pre-treatment of paraffin sections (e.g. trypsin or pronase).
Flow Cytometry: Use 10 µl of 1/10 diluted antibody to label 106 cells in 100 µl.
Recommended Positive Control: Pancreas, placenta.
Reactivity Human
Antibody Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Purified Human placental IGF-I receptor.
Specificity This antibody recognizes CD221, a 155kD receptor tyrosine kinase, also known as Insulin-like growth factor I receptor (IGF-I Receptor). CD221 is composed of two extracellular alpha-subunits and two transmembrane betasubunits.
Clone 1H7 recognizes an epitope in the alpha subunits of CD221, demonstrated by Western blotting. CD221 is expressed in a range of tissues, including kidney, liver, placenta, mammary gland, brain, ovary and skin. The ligands for CD221 include IGF-I and IGF-II, which bind to CD221 and activate tyrosine kinase activity, resulting in phosphorylation of several intracellular signalling proteins.
Clone 1H7 is reported to partically block binding of IGF-I and IGF-II to CD221. We recommend the use of BM2226LE for this purpose.
Buffer PBS
State: Purified
State: Liquid purified IgG fraction from tissue culture supernatant
Preservative: 0.09% Sodium Azide
Concentration lot specific
Purification Affinity Chromatography on Protein G
Conjugation Unconjugated
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Gene Name insulin like growth factor 1 receptor
Database Link
Background There are two kinds of IGF receptors based on their relative affinities for IGF1 versus IGF2. The IGF1 receptor (also known as CD221) prefers IGF1 over IGF2 and weakly binds insulin. IGF1 receptor is a disulfide-linked heterotetrameric transmembrane protein consisting of two alpha (130 kD) and two beta (95 kD) subunits. Both the alpha and beta subunits are encoded within a single receptor precursor cDNA. The IGF1 receptor is therefore similar in structure to the insulin receptor. The proreceptor polypeptide is proteolytically cleaved and disulfide-linked to yield the mature heterotetrameric receptor. The IGF1 receptor is highly expressed in all cell types and tissues and is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.
Synonyms IGF-I receptor, IGF1 Receptor
Reference Data
Protein Categories ADC Targets, Cancer: Gastrointestinal, Cancer: Lung, Cancer: Sarcoma, CD Markers, Cytokines, Endocrine and metabolic diseases, Enzyme: Kinases, Growth Factors, Intracellular Proteins, Membrane Proteins
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Documents
Resources

file-alt Citations

IGF1-R inhibition and liposomal doxorubicin: Progress in preclinical evaluation for the treatment of adrenocortical carcinoma
Beuschlein, Jakoby, Mentz et al
Mol Cell Endocrinol (2016) 428, 82-8 DOI: 10.1016/j.mce.2016.03.023
Cited by 12
AI Summary: OriGene products contributed to this study by providing the IGF-1R antibody (Cat# TA150117) used for immunohistochemical analysis to assess IGF-1R expression in adrenocortical carcinoma xenograft models.
Liposomal doxorubicin for active targeting: surface modification of the nanocarrier evaluated in vitro and in vivo: challenges and prospects
Jakoby, Beuschlein, Mentz et al
Oncotarget (2015) 6 (41), 43698-711 DOI: 10.18632/oncotarget.6191
Cited by 17
AI Summary: In this study, OriGene’s anti-IGF1R antibody (clone 24-31, Cat# TA150040) was used to generate targeted immunoliposomes, enabling the evaluation of active targeting strategies for liposomal doxorubicin both in vitro and in vivo.
FigureFigureFigure
Liposomal doxorubicin-based treatment in a preclinical model of adrenocortical carcinoma
Hantel, Lewrick, Reincke et al
J Endocrinol (2012) 213 (2), 155-61 DOI: 10.1530/JOE-11-0427
AI Summary: In this study, OriGene products—specifically the IGF1R antibody (Cat# TA150118) and the NCI-H295 cell line (Cat# CRL-2128)—were used for in vitro association studies and to establish tumor xenograft models, enabling the evaluation of liposomal doxorubicin-based treatments for adrenocortical carcinoma.
Anti insulin-like growth factor I receptor immunoliposomes: a single formulation combining two anticancer treatments with enhanced therapeutic efficiency
Hantel, Lewrick, Schneider et al
J Clin Endocrinol Metab (2010) 95 (2), 943-52 DOI: 10.1210/jc.2009-1980
Cited by 18
AI Summary: OriGene’s Human IGF1R cDNA clone and IGF1R antibody (TA503321) were used in this study to assess IGF-I receptor expression in tumor samples and cell lines, enabling the evaluation of IGF-I receptor as a therapeutic target for novel anti-IGFI-R immunoliposomes.
Showing 1-4 of 4 papers.
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