BAD pSer91/128 Rabbit Polyclonal Antibody
$330.00
2 Weeks*
Specifications
| Product Data | |
| Application | IHC, WB |
|---|---|
| Recommended Dilution | Western blot: 1:500~1:1000. Immunohistochemistry on paraffin sections: 1:50~1:100. |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Peptide sequence around phosphorylation site of Serine 91 (E-P-S(p)-P-F) derived from Human BAD or Serine 128 (E-P-S(p)-P-F) derived from Mouse BAD (KLH-conjugated) |
| Specificity | The antibody detects endogenous levels of BAD only when phosphorylated at serine 91/ serine 128. |
| Buffer | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol State: Aff - Purified State: Liquid Ig fraction |
| Concentration | lot specific |
| Purification | Affinity chromatography using epitope-specific peptide |
| Conjugation | Unconjugated |
| Storage | Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Predicted Protein Size | 22 kDa |
| Gene Name | BCL2 associated agonist of cell death |
| Database Link | |
| Background | The protein encoded by BAD gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. |
| Synonyms | BAD, BBC6, BCL2L8, Bcl-2-like protein 8, Bcl2-L-8 |
| Reference Data | |
| Protein Categories | Cytokines, Intracellular Proteins |
Reviews
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Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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