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CAMK2A pThr305 Rabbit Polyclonal Antibody

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SKU
AP55687PU-S
CAMK2A pThr305 rabbit polyclonal antibody, Aff - Purified
Size:
50 ul
Conjugation:
Unconjugated
  $330.00
2 Weeks*
Bulk/Customize

View other "CAMK2A or NP_741960.1" antibodies

Specifications
Specifications
Product Data
Application IHC, WB
Recommended Dilution Western blot: 1:500~1:1000.
Immunohistochemistry on paraffin sections: 1:50~1:100.
Reactivity Human, Mouse
Antibody Host Rabbit
Clonality Polyclonal
Immunogen Peptide sequence around phosphorylation site of threonine 305 (I-L-T(p)-T-M) derived from Human CaMK2α/β/δ (KLH-conjugated)
Specificity The antibody detects endogenous levels of CaMKII only when phosphorylated at threonine 305.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
State: Aff - Purified
State: Liquid Ig fraction
Concentration lot specific
Purification Affinity chromatography using epitope-specific peptide
Conjugation Unconjugated
Storage Upon receipt, store undiluted (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Predicted Protein Size 54 kDa
Gene Name calcium/calmodulin dependent protein kinase II alpha
Database Link
Background Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca2+/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca2+ transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca2+ transport and in fast-twitch muscle participates in the control of Ca2+ release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.
Synonyms CAMKA, KIAA0968, CaM-kinase II alpha chain, CaM kinase II subunit alpha, CaMK-II subunit alpha
Reference Data
Protein Categories Enzyme: Kinases, Intracellular Proteins, Membrane Proteins
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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