SUN2 (Center) Rabbit Polyclonal Antibody

CAT#: AP54462PU-N

SUN2 (Center) rabbit polyclonal antibody, Aff - Purified

Product Images

UNC84B Antibody (Center) western blot analysis in MDA-MB435 cell line lysates (35 ug/lane). This demonstrates the UNC84B antibody detected the UNC84B protein (arrow).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1:1;000.
  Western blot: 1:100~500.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 236-265 amino acids from the Central region of human UNC84B
• Specificity: This antibody detects UNC84B (Center).
• Formulation: PBS with 0.09% (W/V) sodium azide
  State: Aff - Purified
  State: Liquid Ig fraction
• Concentration: lot specific
• Purification: Protein A column followed by peptide affinity purification
• Conjugation: Unconjugated
• Storage: Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Sad1 and UNC84 domain containing 2
• Database Link:
  Entrez Gene 25777 Human
  UniProt ID Q9UH99
• Background: SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity (summary by Haque et al., 2010 [PubMed 19933576]).
• Synonyms: FRIGG, KIAA0668, RAB5IP
• Note: Molecular Weight: 80311 Da

Reference Data

• Protein Families: Transmembrane