PCDHA4 (C-term) Rabbit Polyclonal Antibody

CAT#: AP53198PU-N

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PCDHA4 (C-term) rabbit polyclonal antibody, Aff - Purified


 Product Datasheet for 'AP53198PU-N'

USD 415.00


Availability*
2 Weeks

Size
    • 400 ul


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Specifications

Product Data
Applications WB
Recommend Dilution ELISA: 1/1000.
Western blot: 1/100 - 1/500.
Reactivity Human
Host Rabbit
Isotype Ig
Clonality Polyclonal
Immunogen KLH conjugated synthetic peptide between 760-790 amino acids from the C-terminal region of human PCDHA4
Specificity This antibody reacts to PCDHA4.
Formulation PBS
State: Aff - Purified
State: Liquid purified Ig fraction
Preservative: 0.09% (W/V) sodium azide
Concentration lot specific
Purification Affinity chromatography on Protein A
Predicted Protein Size 102293 Da
Gene Name Homo sapiens protocadherin alpha 4 (PCDHA4), transcript variant 1
Background This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.
Synonyms Protocadherin alpha-4, PCDH-alpha-4
Reference Data
Protein Families Transmembrane
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ANTIBODY VALIDATION 101
BOGO Free lysates
68 Mouse Clones