HCAR2 (Center) Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Clone Name | RB31358 |
|---|---|
| Application | WB |
| Recommended Dilution | WB 1:1000 |
| Reactivity | Human |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | KLH conjugated synthetic peptide between 200-228 amino acids from the Central region of Human GPR109A. Antigen Region: Amino acids 200-228. |
| Specificity | This NIACR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 200-228 amino acids of human NIACR1. |
| Buffer | PBS containing 0.09% (W/V) Sodium Azide as preservative State: Aff - Purified State: Liquid purified Ig fraction |
| Concentration | lot specific |
| Purification | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Conjugation | Unconjugated |
| Storage | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Predicted Protein Size | 41850 kDa |
| Gene Name | hydroxycarboxylic acid receptor 2 |
| Database Link | |
| Background | NIACR1 acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide. |
| Synonyms | HM74A, NIACR1, Niacin receptor 1, Nicotinic acid receptor, PUMA-G, Pumag |
| Note | Molecular Weight: 41850 Da |
| Reference Data | |
| Protein Families | Druggable Genome, GPCR, Transmembrane |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
Possible influence of free fatty acid receptors on pH regulation in the ruminal epithelium of sheep
Baaske, Masur, Dengler et al
J Anim Physiol Anim Nutr (Berl) (2020)
Baaske, Masur, Dengler et al
J Anim Physiol Anim Nutr (Berl) (2020)
Cited by 12
AI Summary: In this study, OriGene’s rabbit anti-FFAR2 antibody (Cat. No. SP4226P) and rabbit anti-GPR109A antibody (Cat. No. AP52875PU-N) were used for immunohistochemical detection of FFAR2 and GPR109A receptors in ovine ruminal epithelium, helping to investigate their role in pH regulation.
Showing 1-1 of 1 papers.
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