NEU4 (C-term) Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IHC, WB |
|---|---|
| Recommended Dilution | WB:1/1000, IHC-P:1/50-200 |
| Reactivity | Human, Mouse |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | KLH conjugated synthetic peptide between 430-461 amino acids from the C-terminal region of Human Sialidase-4 |
| Specificity | This NEU4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 423-452 amino acids from the C-terminal region of human NEU4. |
| Buffer | PBS containing 0.09% (W/V) Sodium Azide as preservative State: Aff - Purified State: Liquid purified Ig fraction |
| Concentration | lot specific |
| Purification | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Conjugation | Unconjugated |
| Storage | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Predicted Protein Size | 51.6 kDa |
| Gene Name | neuraminidase 4 (sialidase) |
| Database Link | |
| Background | The protein encoded by this gene belongs to a family of glycohydrolytic enzymes, which remove terminal sialic acid residues from various sialo derivatives, such as glycoproteins, glycolipids, oligosaccharides, and gangliosides. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. |
| Synonyms | NEU4, LP5125, N-acetyl-alpha-neuraminidase 4 |
| Note | Molecular Weight: 51572 Da |
| Reference Data | |
| Protein Pathways | Other glycan degradation, Sphingolipid metabolism |
Reviews
Documents
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Citations
Attenuated pulmonary fibrosis in sialidase-3 knockout (Neu3-/-) mice
Karhadkar, Chen, Gomer
Am J Physiol Lung Cell Mol Physiol (2020) 318 (1), L165-L179 DOI: 10.1152/ajplung.00275.2019
Karhadkar, Chen, Gomer
Am J Physiol Lung Cell Mol Physiol (2020) 318 (1), L165-L179 DOI: 10.1152/ajplung.00275.2019
Cited by 34
Sialidase inhibitors attenuate pulmonary fibrosis in a mouse model
Karhadkar, Pilling, Cox et al
Sci Rep (2017) 7 (1), 15069 DOI: 10.1038/s41598-017-15198-8
Karhadkar, Pilling, Cox et al
Sci Rep (2017) 7 (1), 15069 DOI: 10.1038/s41598-017-15198-8
AI Summary: In this study, OriGene’s recombinant human NEU1, NEU2, NEU3, and NEU4 proteins were used to investigate the effects of sialidases on immune cell activity and fibrosis development in vitro.
Snippet: Where indicated, recombinant 10 ng/ml human TGF-β1 (Peprotech, Rocky Hill, NJ), 200 ng/ml recombinant human NEU1, 2, 3, or 4 (Origene, Rockville, MD), or 2 µg/ml human SAP (EMD Millipore, Billerica, MA;with the azide removed by centrifugal filters following86) were added to cells. Fibrocytes were counted as previously described29,84
Showing 1-2 of 2 papers.
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