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MTMR6 (N-term) Rabbit Polyclonal Antibody

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SKU
AP52768PU-N
MTMR6 Antibody (N-term)
Size:
400 ul
Conjugation:
Unconjugated
  $645.00
2 Weeks*
Bulk/Customize

View other "MTMR6 or NP_004676" antibodies

Specifications
Specifications
Product Data
Clone Name RB36077
Application WB
Recommended Dilution WB 1:1000
Reactivity Human
Antibody Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen KLH conjugated synthetic peptide between 114-143 amino acids from the N-terminal region of Human MTMR6.
Specificity This MTMR6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 114-143 amino acids from the N-terminal region of human MTMR6.
Buffer PBS with 0.09% (W/V) Sodium Azide
State: Aff - Purified
State: Liquid purified Ig fraction
Concentration lot specific
Purification Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Conjugation Unconjugated
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Predicted Protein Size 71968 kDa
Gene Name myotubularin related protein 6
Database Link
Background Phosphatase that acts on lipids with a phosphoinositol headgroup. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol-3 phosphatase. Negatively regulates proliferation of reactivated CD4+ T-cells.
Synonyms Myotubularin-related protein 6
Note Molecular Weight: 71954 Da
Reference Data
Protein Families Druggable Genome, Phosphatase
Protein Pathways Fructose and mannose metabolism, Metabolic pathways, Riboflavin metabolism, Thiamine metabolism
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Documents
Resources

file-alt Citations

INT6 interacts with MIF4GD/SLIP1 and is necessary for efficient histone mRNA translation
Neusiedler, Mocquet, Limousin et al
RNA (2012) 18 (6), 1163-77 DOI: 10.1261/rna.032631.112
Cited by 25
AI Summary: In this study, OriGene products including the INT6/EIF3E shRNA (OriGene, #TF311363) and INT6/EIF3E cDNA clone (OriGene, #RC202507) were used to manipulate INT6 expression levels, enabling the authors to demonstrate INT6's essential role in histone mRNA translation.
Showing 1-1 of 1 papers.
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