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IL10 (Center) Rabbit Polyclonal Antibody

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SKU
AP52181PU-N
IL10 Antibody (Center)
Size:
400 ul
Conjugation:
Unconjugated
  $645.00
2 Weeks*
Bulk/Customize

View other "IL10 or NP_000563" antibodies

Specifications
Specifications
Product Data
Clone Name RB21234
Application FC, IHC, WB
Recommended Dilution WB 1:1000
IHC-P 1:10~50
FC 1:10~50
Reactivity Human
Antibody Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Synthetic peptide - KLH conjugated corresponding to the center region (between aa 27-53) of Human IL10.
Specificity This IL10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 27-53 amino acids from the Central region of human IL10.
Buffer PBS with 0.09% (W/V) Sodium Azide.
State: Aff - Purified
State: Liquid purified Ig fraction
Concentration lot specific
Purification Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Conjugation Unconjugated
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Predicted Protein Size 20517 kDa
Gene Name interleukin 10
Database Link
Background The protein is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract.
Synonyms IL-10, CSIF, TGIF
Note Molecular Weight: 20517 Da
Reference Data
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein
Protein Pathways Allograft rejection, Asthma, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway
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Documents
Resources

file-alt Citations

Neuroinflammatory signals in Alzheimer disease and APP/PS1 transgenic mice: correlations with plaques, tangles, and oligomeric species
López-González, Schlüter, Aso et al
J Neuropathol Exp Neurol (2015) 74 (4), 319-44 DOI: 10.1097/NEN.0000000000000176
AI Summary: OriGene products contributed to this study by providing specific qPCR primers (OriGene, catalog numbers listed in Supplementary Table 2) used for quantitative reverse transcription-PCR analysis of neuroinflammation-related gene expression in mouse and human brain samples.
Complex deregulation and expression of cytokines and mediators of the immune response in Parkinson's disease brain is region dependent
Garcia-Esparcia, Llorens, Carmona et al
Brain Pathol (2014) 24 (6), 584-98 DOI: 10.1111/bpa.12137
Cited by 81
AI Summary: In this study, OriGene products, specifically the IL-6 (TA500733), IL-10 (TA500899), and TNF-α (TA500964) antibodies, were used for protein detection by western blot and immunohistochemistry to assess cytokine expression and localization in Parkinson’s disease brain tissue.
Showing 1-2 of 2 papers.
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