GUCY2D (Center) Rabbit Polyclonal Antibody

CAT#: AP51984PU-N

GUCY2D (Center) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of GUCY2D / GUCY2D / RETGC1 Antibody (Center).-No in Ramos cell line lysates (35ug/lane).This demonstrates the GUCY2D antibody detected the GUCY2D protein (arrow).

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  Immunohistochemistry analysis in formalin fixed and paraffin embedded human thyroid tissue reacted with GUCY2D / GUCY2D / RETGC1 Antibody (Center).-No, which was peroxidase conjugated to the secondary antibody and followed by DAB staining.

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  Flow cytometric analysis of Ramos cells using GUCY2D / GUCY2D / RETGC1 Antibody (Center).-No (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Specifications

Product Data

• Applications: FC, IHC, WB
• Recommended Dilution: Western Blot: 1/1000.
  Flow Cytometry: 1/10-1/50.
  Immunohistochemistry on Paraffin Sections: 1/50-1/100.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 540-570 amino acids from the Central region of human GUCY2D / RETGC1
• Specificity: This antibody recognizes Human GUCY2D / RETGC1 (Center).
• Formulation: PBS containing 0.09% (W/V) Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Protein A column, followed by peptide affinity purification
• Conjugation: Unconjugated
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: guanylate cyclase 2D, retinal
• Database Link:
  Entrez Gene 3000 Human
  UniProt ID Q02846
• Background: This gene encodes a retina-specific guanylate cyclase, which is a member of the membrane guanylyl cyclase family. Like other membrane guanylyl cyclases, this enzyme has a hydrophobic amino-terminal signal sequence followed by a large extracellular domain, a single membrane spanning domain, a kinase homology domain, and a guanylyl cyclase catalytic domain. In contrast to other membrane guanylyl cyclases, this enzyme is not activated by natriuretic peptides. Mutations in this gene result in Leber congenital amaurosis and cone-rod dystrophy-6 diseases. [provided by RefSeq].
• Synonyms: Retinal guanylyl cyclase 1, RETGC-1, retinal Guanylate cyclase 2D, CORD6, GUC1A4, GUC2D, RETGC, PGCD
• Note: Molecular Weight: 120059 Da

Reference Data

• Protein Families: Druggable Genome, Protein Kinase, Transmembrane
• Protein Pathways: Olfactory transduction, Purine metabolism