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HRH2 (C-term) Goat Polyclonal Antibody

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SKU
AP33416PU-N
HRH2 (C-term) goat polyclonal antibody, Aff - Purified
Size:
100 ug
Conjugation:
Unconjugated
  $565.00
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View other "HRH2 or NP_071640.1" antibodies

Specifications
Specifications
Product Data
Application FC, IF, PEP-ELISA, WB
Recommended Dilution Peptide ELISA: 1/128000 (Detection Limit).
Western blot: Preliminary experiments gave bands at approx 55kDa and a stronger 28kDa in Human Colon and Duodenum lysates after 0.1 µg/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the bands we observe given the calculated size of 40.1kDa according to NP_071640.1. Both detected bands were successfully blocked by incubation with the immunizing peptide (and BLAST results with the immunizing peptide sequence did not identify any other proteins to explain the additional bands).
Immunohistochemistry/Immunofluorescence: This antibody was successfully used on coronal Rat brain slices as reported in Peng et al, Neurosci Lett. 2013 Apr 29;541:87-92. PMID:23466693.
Reactivity Canine, Human, Mouse, Rat
Antibody Host Goat
Clonality Polyclonal
Immunogen Peptide with sequence from the C-Terminus of the protein sequence according to NP_071640.1; NP_001124527.1.
Specificity This antibody is expected to recognise both reported isoforms.
Buffer Tris saline, pH~7.3
State: Aff - Purified
State: Liquid purified Ig fraction
Stabilizer: 0.5% BSA
Preservative: 0.02% Sodium Azide
Concentration lot specific
Purification Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
Conjugation Unconjugated
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Gene Name histamine receptor H2
Database Link
Synonyms H2R, HRH2, Gastric receptor I
Reference Data
Protein Categories GPCR, Membrane Proteins
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Documents
Resources

file-alt Citations

Histamine Increases Neuronal Excitability and Sensitivity of the Lateral Vestibular Nucleus and Promotes Motor Behaviors via HCN Channel Coupled to H2 Receptor
Li, Zhang, Yang et al
Front Cell Neurosci (2016) 10, 300 DOI: 10.3389/fncel.2016.00300
Cited by 21
AI Summary: In this study, OriGene’s anti-HCN1 antibody (Cat# TA326459) and anti-HCN2 antibody (Cat# TA326464) were used for immunohistochemical analysis to detect the expression and localization of HCN channels in the lateral vestibular nucleus, supporting the investigation of histamine’s effects on neuronal excitability and motor behavior.
FigureFigureFigure
Selective Modulation of Histaminergic Inputs on Projection Neurons of Cerebellum Rapidly Promotes Motor Coordination via HCN Channels
Zhang, Zhuang, Li et al
Mol Neurobiol (2016) 53 (2), 1386-1401 DOI: 10.1007/s12035-015-9096-3
Cited by 29
AI Summary: In this study, OriGene's anti-HCN2 antibody (Cat# TA322354) was used to specifically detect HCN2 channel expression in cerebellar neurons, helping to elucidate the role of HCN channels in histaminergic modulation of motor coordination.
Postsynaptic mechanisms underlying the excitatory action of histamine on medial vestibular nucleus neurons in rats
Zhang, Yu, Zhuang et al
Br J Pharmacol (2013) 170 (1), 156-69 DOI: 10.1111/bph.12256
Cited by 55
AI Summary: In this study, OriGene products—including specific primers for quantitative real-time RT-PCR targeting H₁, H₂, and H₄ histamine receptors, as well as NCX and HCN channel subtypes—were used to assess mRNA expression levels, thereby helping to elucidate the molecular mechanisms underlying histamine's excitatory actions on medial vestibular nucleus neurons.
Histamine excites neurons of the inferior vestibular nucleus in rats by activation of H1 and H2 receptors
Peng, Zhuang, He et al
Neurosci Lett (2013) 541, 87-92 DOI: 10.1016/j.neulet.2013.02.040
Cited by 28
AI Summary: In this study, OriGene products including rat Hrh1 (NM_017102) and Hrh2 (NM_012966) qPCR primers were used to assess the expression of histamine H1 and H2 receptors, helping to confirm their involvement in histamine-induced excitation of inferior vestibular nucleus neurons.
Showing 1-4 of 4 papers.
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