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TIMP-3 (Tissue Inhibitor of Metalloproteinase-3) Rabbit Polyclonal Antibody

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SKU
AP32837PU-T
TIMP-3 (Tissue Inhibitor of Metalloproteinase-3) rabbit polyclonal antibody, Purified
Size:
20 ug
Conjugation:
Unconjugated
  $370.00
2 Weeks*
Bulk/Customize

View other "TIMP3 or NP_000353.1" antibodies

Specifications
Specifications
Product Data
Application FC, IF, IHC, IP, WB
Recommended Dilution Flow Cytometry: 0.5-1 µg/106 cells.
Immunofluorescence: 1-2 µg/ml.
Western Blotting: 0.5-1 µg/ml.
Immunoprecipitation: 1-2 µg/500 µg protein lysate.
Immunohistochemistry on Formalin-Fixed Paraffin Sections: 1/200-1/400 for 30 minutes at RT.
Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.
Positive Control: Placenta or breast carcinoma.
Reactivity Bovine, Canine, Cow, Dog, Equine, Horse, Human, Mouse, Rat
Antibody Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen The amino acid sequence (aa175-211), used as the immunogen for TIMP3 Ab, is 100% homologous in human, cow, dog and horse, and 94% homologous in Mouse and rat.
Specificity Cellular Localization: Extracellular matrix, Extracellular space, Secreted
Buffer 200ug/ml of Ab Purified from rabbit anti-serum by Protein A. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml.
Concentration lot specific
Purification Protein A Chromatography
Conjugation Unconjugated
Storage Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Predicted Protein Size 30kDa
Gene Name TIMP metallopeptidase inhibitor 3
Database Link
Background TIMP3 (tissue inhibitor of metalloproteinases 3), along with family members TIMP1, TIMP2, and TIMP4, are inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix (ECM). An imbalance between MMPs and the associated TIMPs may play a significant role in the invasive phenotype of malignant tumors. TIMP's inhibit the proteolytic invasiveness of tumor cells and normal placental trophoblast cells. TIMP-3 may be involved in regulating trophoblastic invasion of the uterus as well as in regulating remodeling of the extracellular matrix during the folding of epithelia, and in the formation, branching and expansion of epithelial tubes.
Synonyms HSMRK222, K222TA2, Protein MIG-5, SFD, Sorsby fundus dystrophy pseudo-inflammatory, TIMP metallopeptidase inhibitor 3, Tissue Inhibitor of Metalloproteinase 3
Reference Data
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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