PACE4 (PCSK6) Goat Polyclonal Antibody
$565.00
5 Days*
Specifications
| Product Data | |
| Application | ELISA, IHC |
|---|---|
| Recommended Dilution | Peptide ELISA: Detection Limit: 1/32000. Western Blot: Preliminary experiments gave an approx 40-45 kDa band in Human Brain (Cerebellum) lysates after 0.2 µg/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 106 kDa according to NP_002561.1. The 40-45 kDa band was successfully blocked by incubation with the immunizing peptide. Immunohistochemistry on Paraffin Sections: 5-10 µg/ml. In Paraffin Embedded Human Skeletal Muscle shows striated staining in alternating fibres. |
| Reactivity | Human |
| Antibody Host | Goat |
| Clonality | Polyclonal |
| Immunogen | Peptide with sequence from the internal region of the protein sequence according to NP_002561.1; NP_612192.1; NP_612195.1; NP_612197.1; NP_612196.1; NP_612198.2; NP_612193.1; NP_612194.1. |
| Specificity | Recognizes PCSK6 / PACE4. This antibody is expected to recognize reported isoforms a (NP_002561.1), b (NP_612192.1), g (NP_612193.1) and h (NP_612194.1). |
| Buffer | Tris saline, pH~7.3 with 0.02% Sodium Azide and 0.5% BSA State: Aff - Purified State: Liquid purified Ig fraction |
| Concentration | lot specific |
| Purification | Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide |
| Conjugation | Unconjugated |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Gene Name | proprotein convertase subtilisin/kexin type 6 |
| Database Link | |
| Background | PACE4 belongs to the peptidase S8 family. Likely to represent an endoprotease activity within the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues and capable of cleavage at the RX(K/R)R consensus motif. Each PACE4 isoform exhibits a unique restricted distribution. Isoform PACE4A-I is expressed in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, but at comparatively higher levels in the liver. Isoform PACE4A-II is at least expressed in placenta. Isoform PACE4B was only found in the embryonic kidney cell line from which it was isolated. Isoform PACE4C and isoform PACE4D are expressed in placenta. Isoform PACE4E-I is expressed in cerebellum, placenta and pituitary. Isoform PACE4E-II is at least present in cerebellum. |
| Synonyms | SPC4 |
| Reference Data | |
| Protein Categories | Enzyme: Peptidases, Growth Factors, Intracellular Proteins, Secreated Proteins |
| Protein Families | Druggable Genome, Protease, Secreted Protein |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
Related Products
- Price:
- Actual Price:
Welcome to OriGene AI!
I'm your AI-powered guide to everything OriGene.
Ask me anything:
- Product specs
- Ordering help
- Technical questions
- How to find exactly what your experiment needs
Prefer a live agent? Connect with us by clicking the green chat icon, as seen in the image below or email our team at custsupport@origene.com.
