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Snap25 pSer187 Rabbit Polyclonal Antibody

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SKU
AP26444PU-N
Snap25 pSer187 rabbit polyclonal antibody, Aff - Purified
Size:
100 ul
Conjugation:
Unconjugated
  $610.00
3 Days*
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View other "Snap25 or NP_112253.1" antibodies

Specifications
Specifications
Product Data
Application WB
Recommended Dilution Western blot: 1/1000.
Reactivity Guinea Pig, Human, Mouse, Primate, Rat, Zebrafish
Antibody Host Rabbit
Isotype Ig
Clonality Polyclonal
Immunogen Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser187 of SNAP25
Specificity Specific for the ~25k SNAP25 protein phosphorylated at Ser 187 in Western blots. Immunolabeling is completely blocked by blocked λ -Ptase.
Buffer 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 μg BSA per ml and 50% glycerol
State: Aff - Purified
State: Liquid Ig fraction
Purification Affinity purification via sequential chromatography on phospho- and dephosphopeptide affinity columns
Conjugation Unconjugated
Storage Upon receipt, store undiluted (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Gene Name synaptosomal-associated protein 25
Database Link
Background SNAP25 (Synaptosomal associated pr otein of 25 kDa) is a presynaptic plasma membrane protein that is widely distributed throughout the brain and involved in the regulation of neurotransmitter release. Decreased levels of SNAP25 have been found in the brains of patients with Down Syndrome and Alzheimer’s Disease (Greber et al., 1999). In addition, a significant reduction in the hippocampal expression of SNAP25 has also been found in patients with Schizophrenia (Fatemi et al., 2001). Increasing evidence suggests that SNAP-25 also modulates various ion channels, including voltage gated calcium channels (VGCCs) (Pozzi el al., 2008). Activation of PKC results in the phosphorylation of SNAP-25 on ser187 (Shu et al ., 2008). Phosphorylation of SNAP25 on ser187 is believed to cause inhibition of VGCC (Pozzi el al., 2008). Since ser187 phosphorylation is transiently induced by neuronal activity, SNAP25 creates a negative feedback mechanism for controlling neuronal excitability (Pozzi el al., 2008).
Synonyms SNAP-25, SUP, SNAP, Super Protein, RIC4, ric-4
Reference Data
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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