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c Kit (KIT) pTyr719 Rabbit Polyclonal Antibody

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SKU
AP26418AF-N
c Kit (KIT) pTyr719 rabbit polyclonal antibody, Azide Free
Size:
100 ug
Conjugation:
Unconjugated
  $565.00
2 Weeks*
Bulk/Customize

View other "KIT or NP_000213.1" antibodies

Specifications
Specifications
Product Data
Application ELISA
Recommended Dilution ELISA: The antibody (approx. 1:64,000 diluted) can detect the above Tyr 719 phosphorylated c-kit peptide coated on ELISA plate.
Reactivity Human, Mouse
Antibody Host Rabbit
Clonality Polyclonal
Immunogen A synthetic peptide derived from tyrosine 719 phosphorylated c-kit, conjugated with KLH
Specificity This antibody reacts with Mouse, Human and other species with consensus c-kit peptide (SDSTNEYpMDMKPG).
Buffer 0.01M PBS, pH 7.4
State: Azide Free
State: Lyophilized Ig fraction
Reconstitution Method Restore with Double distilled water to adjust the final concentration to 1.00mg/ml.
Purification Protein G affinity
Conjugation Unconjugated
Storage Store lyophilized at 2-8°C for 6 month or at -20°C long term.
After reconstitution store the antibody undiluted at 2-8°C for one month
or (in aliquots) at -20°C long term.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Shipping Ambient
Gene Name KIT proto-oncogene receptor tyrosine kinase
Database Link
Background c-kit, also known as CD117, is a receptor tyrosine kinase expressed at the surface of mast cells and certain types of stem cells. c-kit is activated and autophosphorylated upon binding with stem cell factor. Activated c-kit phosphorylates downstream SH2- domain-containing signalling molecules such as PLCγ, the p85 subunit of PI3 kinase, SHP2, and CrkL. The binding is impaired when c-kit is mutated at tyrosine719. c-kit with phosphorylated tyrosine 719 binds to the p85 subunit of PI3 kinase in vitro and in vivo. C-kit is encoded by KIT gene and the gene is frequently over-expressed in gastrointestinal stromal tumor, myelogenous leukemia, and testicular germ cell tumor. Mutational loci of the gene are implicated with responsiveness to cancer drug imatinib.
Synonyms SCFR, KIT
Reference Data
Protein Categories ADC Targets, Allergies and autoimmune diseases, Cancer: Gastrointestinal, Cancer: Gynecologic, Cancer: Haematopoietic and Lymphoid, CD Markers, Cytokines, Enzyme: Kinases, Growth Factors, Intracellular Proteins, Membrane Proteins
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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