Serpinb9 Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | FC, WB |
|---|---|
| Recommended Dilution | Flow Cytometry: The typical starting working dilution is 1/50. Western blot: The typical starting working dilution is 1/50. |
| Reactivity | Mouse |
| Antibody Host | Rabbit |
| Isotype | Ig |
| Clonality | Polyclonal |
| Immunogen | Recombinant GST-Spi-6 |
| Specificity | The antibody recognizes Mouse Spi-6, also known as Serpin B9, a cytoplasmic serine protease inhibitor of ~42 kDa. It shows no cross-reactivity with Mouse proteins related to Spi-6. |
| Buffer | PBS State: Purified State: Liquid 0.2 µm filtered Ig fraction Stabilizer: 0.1% BSA Preservative: 0.02% Sodium Azide |
| Concentration | lot specific |
| Purification | Protein A Chromatography |
| Conjugation | Unconjugated |
| Storage | Store undiluted at 2-8°C. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Gene Name | serine (or cysteine) peptidase inhibitor, clade B, member 9 |
| Database Link | |
| Background | Spi-6 is expressed in dendritic cells, lymphocytes and specific cell types at immune-privileged sites. It inactivates granzyme B, a natural occurring inducer of programmed cell death. As such, Spi-6 functions as anti-apoptotic protein. In cytotxic T cells (CTL), Spi-6 is required to protect clonal bursts (expansion) from granzyme B induced cell death. However, it is not required for the development of memory cells. Expression of SPI-6 is of crucial importance in the escape of several tumors from a CTL response and is, therefore, a parameter that influences the feasibility of CTL-mediated immunotherapy of cancer. |
| Synonyms | Cytoplasmic antiproteinase 3, serpin B9, PI-9 |
| Reference Data | |
Reviews
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Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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