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PKM2 (PKM) (Isoform M1) Rabbit Polyclonal Antibody

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SKU
AP26075PU-S
PKM2 (PKM) (Isoform M1) rabbit polyclonal antibody, Aff - Purified
Size:
50 ul 100 ul
Conjugation:
Unconjugated
  $330.00
2 Weeks*
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View other "PKM2 or NP_002645" antibodies

Specifications
Specifications
Product Data
Application IF, WB
Recommended Dilution Western blot: 1/1000.
Immunofluorescence.
Reactivity Human, Mouse
Antibody Host Rabbit
Clonality Polyclonal
Immunogen Peptide sequence around aa. 399~403 derived from Human PKM1.
Specificity This antibody detects endogenous levels of total PKM1 protein.
Buffer Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% Sodium Azide and 50% Glycerol
State: Aff - Purified
State: Liquid purified Ig fraction
Concentration lot specific
Purification Affinity-chromatography using epitope-specific peptide
Conjugation Unconjugated
Storage Upon receipt, store undiluted (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Predicted Protein Size 60 kDa
Gene Name pyruvate kinase, muscle
Database Link
Background Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.
Synonyms PK2, PK3, PKM, CTHBP, M2-PK, THBP1, OIP3, OIP-3, Pyruvate kinase 2/3, Pyruvate kinase M1/M2, Pyruvate kinase muscle
Reference Data
Protein Categories Intracellular Proteins
Protein Families Druggable Genome
Protein Pathways Glycolysis / Gluconeogenesis, Metabolic pathways, Purine metabolism, Pyruvate metabolism, Type II diabetes mellitus
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Documents
Resources

file-alt Citations

PKM2 phosphorylates MLC2 and regulates cytokinesis of tumour cells
Jiang, Wang, Wang et al
Nat Commun (2014) 5, 5566 DOI: 10.1038/ncomms6566
Cited by 145
AI Summary: In this study, OriGene products—including the PKM2 (RC200307) and PKM1 (RC200308) expression plasmids—were used to investigate the specific roles of PKM2 and PKM1 in regulating cytokinesis and tumor cell proliferation.
FigureFigureFigure
Showing 1-1 of 1 papers.
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