Suppressor of Fused (SUFU) pSer342 Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | WB |
|---|---|
| Recommended Dilution | Western blot: 1:500 - 1:1000. |
| Reactivity | Human |
| Antibody Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Peptide sequence around phosphorylation site of Serine 342 derived from Human Sufu |
| Specificity | This antibody detects endogenous level of Sufu protein only when phosphorylated at serine 342. |
| Buffer | Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol State: Aff - Purified State: Liquid Ig fraction |
| Concentration | lot specific |
| Purification | Affinity-chromatography using epitope-specific peptide |
| Conjugation | Unconjugated |
| Storage | Store (in aliquots) at -20 °C. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Gene Name | SUFU negative regulator of hedgehog signaling |
| Database Link | |
| Background | SUFU encodes a component of the Sonic hedgehog (SHH; MIM 600725)/Patched (PTCH; MIM 601309) signaling pathway. Mutations in genes encoding components of this pathway are deleterious for normal development and are associated with cancer-predisposing syndromes (e.g., HPE3, MIM 142945; BCNS, MIM 109400; and GCPS, MIM 175700). |
| Synonyms | Suppressor of fused homolog |
| Note | Molecular weight: 54 kDa |
| Reference Data | |
| Protein Categories | Cancer: Brain and CNS, Intracellular Proteins |
| Protein Families | Druggable Genome, Transcription Factors |
| Protein Pathways | Basal cell carcinoma, Hedgehog signaling pathway, Pathways in cancer |
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