Caspase 2 (CASP2) (C-term) Rabbit Polyclonal Antibody

SKU AP23372PU-N

Caspase 2 (CASP2) (C-term) rabbit polyclonal antibody, Aff - Purified

Product Data

• Application: IHC, WB
• Recommended Dilution: Western blot: Use 1 μg/ml with the appropriate system to detect Caspase 2 in cells and tissues.; Immunohistochemistry on Paraffin Sections: A previous lot of this antibody has been used at 1-2 μg/ml to detect Caspase 2 in formalin fixed and paraffin embedded tissues.
• Reactivity: Human, Mouse, Rat
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide mapping at the C-terminal of Human Caspase 2
• Specificity: This antibody detects Caspase-2 (C-term). No cross reactivity with other proteins.
• Buffer: 0.9 mg NaCl, 0.2 mg Na2HPO4; State: Aff - Purified; State: Lyophilized purified Ig fraction; Stabilizer: 5 mg BSA; Preservative: 0.05 mg Thimerosal, 0.05 mg Sodium Azide
• Reconstitution Method: 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
• Purification: Immunoaffinity Chromatography
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20 °C for longer. ; Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Shipping: Ambient
• Gene Name: caspase 2
• Database Link:
  P42575
• Background: Caspase-2, which is involved in stress-induced apoptosis, is recruited into a large protein complex, the molecular composition of which remains elusive. activation of caspase-2 occurs in a complex that contains the death domain-containing protein PIDD, whose expression is induced by p53, and the adaptor protein RAIDD. Increased PIDD expression resulted in spontaneous activation of caspase-2 and sensitization to apoptosis by genotoxic stimuli. Caspase-2 acts both as a positive and negative cell death effector, depending upon cell lineage and stage of development.
• Synonyms: CASP-2, CASP2, ICH1, ICH-1 protease, NEDD2

Reference Data

• Protein Families: Druggable Genome, Protease