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PDGF beta (PDGFB) (222-233) Goat Polyclonal Antibody

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SKU
AP23139PU-N
PDGF beta (PDGFB) (222-233) goat polyclonal antibody, Aff - Purified
Size:
50 ug
Conjugation:
Unconjugated
  $595.00
3 Weeks*
Bulk/Customize

View other "PDGF beta or NP_002599" antibodies

Specifications
Specifications
Product Data
Application IHC
Recommended Dilution Immunohistochemistry on Paraffin Sections: 3.75 µg/ml.
Reactivity Bovine, Human, Sheep
Antibody Host Goat
Clonality Polyclonal
Immunogen Synthetic peptide from C-Terminus of human PDGFB (NP_002599.1; NP_148937.1)
Specificity This antibody detects PDGFB (C-term).
Buffer Tris saline, pH 7.3 containing 0.02% sodium azide as preservative and 0.5% BSA as stabilizer
State: Aff - Purified
State: Liquid purified Ig fraction
Concentration lot specific
Purification Immunoaffinity Chromatography
Conjugation Unconjugated
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Gene Name platelet derived growth factor subunit B
Database Link
Background PDGF-B is the major polypeptide mitogen in serum for cells of mesenchymal origin; it promotes cellular proliferation and inhibits apoptosis.
Synonyms Platelet-derived growth factor subunit B, PDGF beta, PDGF B, PDGF-B, Platelet-derived growth factor beta, PDGF subunit B, Platelet-derived growth factor B chain, PDGF2, PDGF-2, c-Sis, SIS, Becaplermin
Reference Data
Protein Categories Cancer: Brain and CNS, Cancer: Lung, Growth Factors, Intracellular Proteins, Nervous system: Neurodegenerative diseases, Secreated Proteins
Protein Families Druggable Genome
Protein Pathways Cytokine-cytokine receptor interaction, Focal adhesion, Gap junction, Glioma, MAPK signaling pathway, Melanoma, Pathways in cancer, Prostate cancer, Regulation of actin cytoskeleton, Renal cell carcinoma
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Documents
Resources

file-alt Citations

Lysophosphatidic acid increases proximal tubule cell secretion of profibrotic cytokines PDGF-B and CTGF through LPA2- and Gαq-mediated Rho and αvβ6 integrin-dependent activation of TGF-β
Geng, Lan, Singha et al
Am J Pathol (2012) 181 (4), 1236-49 DOI: 10.1016/j.ajpath.2012.06.035
Cited by 99
AI Summary: In this study, OriGene’s Lpar2 (NM_020029) and Itgb6 (NM_008398) qPCR primers were used to measure gene expression levels of LPA2 and β6 integrin, respectively, helping to elucidate their roles in LPA-induced profibrotic signaling in kidney proximal tubule cells.
Showing 1-1 of 1 papers.
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