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IKK alpha (CHUK) (+IKKB) Rabbit Polyclonal Antibody

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SKU
AP21040PU-N
IKK alpha (CHUK) (+IKKB) rabbit polyclonal antibody, Aff - Purified
Size:
100 ug
Conjugation:
Unconjugated
  $495.00
7 Weeks*
Bulk/Customize

View other "IKK alpha or NP_001269" antibodies

Specifications
Specifications
Product Data
Application IHC
Recommended Dilution IHC:1/50-200
Reactivity Human, Mouse, Rat
Antibody Host Rabbit
Clonality Polyclonal
Specificity IKKa/b pAb detects endogenous levels of IKKa/b protein.
Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
State: Aff - Purified
State: Liquid purified Ig fraction
Concentration 1,0 mg/ml
Purification Affinity chromatography (> 95% (by SDS-PAGE)
Conjugation Unconjugated
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Gene Name conserved helix-loop-helix ubiquitous kinase
Database Link
Background The transcription factor NFkappaB is retained in the cytoplasm in an inactive form by the inhibitory protein IkappaB. Activation of NFkappaB requires that IkappaB be phosphorylated on specific serine residues, which results in targeted degradation of IkappaB. IkappaB kinase alpha (IKKalpha), previously designated CHUK, interacts with IkappaBalpha and specifically phosphorylates IkappaBalpha on Serine 32 and 36, the sites that trigger its degradation. IKKalpha appears to be critical for NFkappaB activation in response to proinflammatory cytokines. Phosphorylation of IkappaB by IKKalpha is stimulated by the NFkappaB inducing kinase (NIK), which itself is a central regulator for NFkappaB activation in response to TNF and IL-1. The functional IKK complex contains three subunits, IKKalpha, IKKbeta and IKKgamma (also designated NEMO), and each appear to make essential contributions to IkappaB phosphorylation.
Synonyms CHUK, TCF16, I kappa-B kinase alpha, IkBKA, IKK-alpha, IKK-A, IkappaB kinase, I-kappa-B kinase 1, NFKBIKA, IKK1
Reference Data
Protein Families Druggable Genome, Protein Kinase
Protein Pathways Acute myeloid leukemia, Adipocytokine signaling pathway, Apoptosis, B cell receptor signaling pathway, Chemokine signaling pathway, Chronic myeloid leukemia, Cytosolic DNA-sensing pathway, Epithelial cell signaling in Helicobacter pylori infection, MAPK signaling pathway, NOD-like receptor signaling pathway, Pancreatic cancer, Pathways in cancer, Prostate cancer, RIG-I-like receptor signaling pathway, Small cell lung cancer, T cell receptor signaling pathway, Toll-like receptor signaling pathway
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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