HSF1 pSer303 Rabbit Polyclonal Antibody
$525.00
7 Weeks*
Specifications
| Product Data | |
| Application | IF, IHC |
|---|---|
| Recommended Dilution | IHC:1/50-200, IF:1/50-200 |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Clonality | Polyclonal |
| Specificity | This antibody detects endogenous levels of p-HSF1 protein. |
| Buffer | Phosphate buffered saline (PBS), pH 7.2. State: Aff - Purified State: Liquid purified Ig fraction Preservative: 0.05% sodium azide |
| Concentration | 1.0 mg/ml |
| Purification | Affinity chromatography (> 95% (by SDS-PAGE) |
| Conjugation | Unconjugated |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Predicted Protein Size | ~ 82 kDa |
| Gene Name | heat shock transcription factor 1 |
| Database Link | |
| Background | Prokaryotic and eukaryotic cells respond to thermal and chemical stress by inducing a group of genes collectively designated heat shock genes. In eukaryotes, this gene expression is regulated primarily at the transcription level. Heat shock transcription factors (HSF, also designated HSTF) 1 and 2 are involved in this regulation. HSF1 and HSF2 are upregulated by estrogen at both the mRNA and protein level. HSF1 is normally found as a monomer whose transcriptional activity is repressed by constitutive phosphorylation. Upon activation, HSF1 forms trimers, gains DNA binding activity and is translocated to the nucleus. HSF2 activity is associated with differentiation and development and, like HSF1, binds DNA as a trimer. Both HSF1 and HSF2 are known to be induced by proteasome inhibitors of the ubiquitin pathway. Phosphorylation of HSF1 on Ser 230 by heat shock has been shown to positively contribute to the transcriptional activity of HSF1. |
| Synonyms | HSTF1, HSF-1 |
| Reference Data | |
| Protein Categories | Intracellular Proteins, Transciption Factors |
| Protein Families | Transcription Factors |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
Estimates of exposure to cold before death from immunohistochemical expression patterns of HSP70 in glomerular podocytes
Sakurada, Asano, Takahashi et al
Int J Legal Med (2013) 127 (4), 783-90 DOI: 10.1007/s00414-012-0806-3
Sakurada, Asano, Takahashi et al
Int J Legal Med (2013) 127 (4), 783-90 DOI: 10.1007/s00414-012-0806-3
Cited by 13
AI Summary: OriGene products contributed to this study by providing the anti-HSP70 antibody (Cat# TA500439), which was used for immunohistochemical analysis to detect HSP70 expression patterns in glomerular podocytes and help estimate exposure to cold before death.
Showing 1-1 of 1 papers.
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