5 HT1F (HTR1F) Rabbit Polyclonal Antibody

SKU AP20470PU-N

5 HT1F (HTR1F) rabbit polyclonal antibody, Aff - Purified

Product Data

• Application: IF, WB
• Recommended Dilution: Western blot: 1/500 - 1/1000.; Immunofluorscence: 1/50 - 1/200.
• Reactivity: Human, Mouse, Rat
• Antibody Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of SR-1F protein.; (region surrounding Thr126)
• Buffer: Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.; State: Aff - Purified; State: Liquid purified Ig fraction
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography (> 95% (by SDS-PAGE)
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.; Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Predicted Protein Size: ~ 38 kDa
• Gene Name: 5-hydroxytryptamine receptor 1F
• Database Link:
  P30939
• Background: The members of the G protein-coupled receptor family are distinguished by their slow transmitting response to ligand binding. These seven transmembrane proteins include the adrenergic, serotonin and dopamine receptors. The effect of the signaling molecule can be excitatory or inhibitory depending on the type of receptor to which it binds. beta-adrenergic bound to adrenaline activates adenylyl cyclase, while alpha2-adrenergic receptor bound to adrenaline inhibits adenylyl cyclase. Like the alpha2-adrenergic receptor, serotonin receptor functions are also mediated by G proteins that inhibit the activity of adenylyl cyclase. The serotonin receptors have been classified into several categories, designated SR-1–7 (5HT1–7). Subtypes within the SR-1 group include SR-1A, -1B, -1D, -1E and -1F.
• Synonyms: 5-hydroxytryptamine receptor 1F, HTR1EL, 5-HT-1F

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Neuroactive ligand-receptor interaction