alpha 2b Adrenergic Receptor (ADRA2B) Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | FC, IF, IHC, WB |
|---|---|
| Recommended Dilution | WB:1/1000, IHC-P:1/50-200, IF:1/10-50, FC:1/10-50 |
| Reactivity | Human |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | KLH conjugated synthetic peptide between 343-369 amino acids from the Center region of Human ADRA2B. |
| Specificity | This ADRA2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 343-369 amino acids from the Central region of human ADRA2B. |
| Buffer | PBS with 0.09% (W/V) Sodium Azide as preservative State: Aff - Purified State: Liquid purified Ig fraction |
| Concentration | lot specific |
| Purification | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Conjugation | Unconjugated |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Predicted Protein Size | 50 kDa |
| Gene Name | adrenoceptor alpha 2B |
| Database Link | |
| Background | Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Alpha 2B adrenergic receptor subtype was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. Alpha 2B adrenergic receptor gene contains no introns in either its coding or untranslated sequences. |
| Synonyms | ADRA2L1, ADRA2RL1, Alpha-2B adrenoreceptor, Alpha-2B adrenoceptor |
| Reference Data | |
| Protein Families | Druggable Genome |
| Protein Pathways | Neuroactive ligand-receptor interaction |
Reviews
Documents
| Product Manuals |
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Citations
Distribution and relative expression of vasoactive receptors on arteries
Liu, Luo, Zhang et al
Sci Rep (2020) 10 (1), 15383 DOI: 10.1038/s41598-020-72352-5
Liu, Luo, Zhang et al
Sci Rep (2020) 10 (1), 15383 DOI: 10.1038/s41598-020-72352-5
Cited by 22
AI Summary: OriGene products—specifically the ADRA1D antibody (TA328712) and ADRA2B antibody (AP17872PU-N)—were used in this study to detect and analyze the expression of vasoactive receptors in different human arteries.
Snippet: no. ab137123, Abcam, Cambridge, UK), ADRA1B (ab169523, Abcam), ADRA1D (TA328712, Origene, Rockville, MD USA), ADRA2A (ab85570, Abcam), ADRA2B (AP17872PU-N, Origene), and ADRA2C (ab151618, Abcam);- no. ab137123, Abcam, Cambridge, UK), ADRA1B (ab169523, Abcam), ADRA1D (TA328712, Origene, Rockville, MD USA), ADRA2A (ab85570, Abcam), ADRA2B (AP17872PU-N, Origene), and ADRA2C (ab151618, Abcam)
Showing 1-1 of 1 papers.
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