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PHLPP (PHLPP1) (N-term) Rabbit Polyclonal Antibody

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SKU
AP14678PU-N
PHLPP1 Antibody (N-term)
Size:
400 ul
Conjugation:
Unconjugated
  $645.00
2 Weeks*
Bulk/Customize
Specifications
Specifications
Product Data
Application WB
Recommended Dilution WB:1/1000
Reactivity Human
Antibody Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human PHLPP1.
Specificity This PHLPP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 531-560 amino acids from the N-terminal region of human PHLPP1.
Buffer PBS with 0.09% (W/V) sodium azide
State: Purified
State: Liquid purified Ig
Concentration lot specific
Purification Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Conjugation Unconjugated
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Predicted Protein Size 184.7 kDa
Gene Name PH domain and leucine rich repeat protein phosphatase 1
Database Link
Background PHLPP1 is a protein phosphatase that specifically mediates dephosphorylation of 'Ser-473' of AKT1, a protein that regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes.
Synonyms PHLPP, PLEKHE1, SCOP, KIAA0606
Reference Data
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Documents
Resources

file-alt Citations

PHLPP1 splice variants differentially regulate AKT and PKCα signaling in hippocampal neurons: characterization of PHLPP proteins in the adult hippocampus
Jackson, Verrier, Semple-Rowland et al
J Neurochem (2010) 115 (4), 941-55 DOI: 10.1111/j.1471-4159.2010.06984.x
Cited by 35
AI Summary: OriGene products, including anti-PHLPP1 antibody (Cat# TA324945) and PHLPP1 expression plasmids, were used in this study to detect and manipulate PHLPP1 protein levels, enabling the authors to characterize the distinct roles of PHLPP1 splice variants in regulating AKT and PKCα signaling in hippocampal neurons.
FigureFigure
Showing 1-1 of 1 papers.
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