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alpha Actinin 4 (ACTN4) (N-term) Rabbit Polyclonal Antibody

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SKU
AP14583PU-N
ACTN4 Antibody (N-term)
Size:
400 ul
Conjugation:
Unconjugated
  $645.00
2 Weeks*
Bulk/Customize
Specifications
Specifications
Product Data
Application WB
Recommended Dilution WB:1/1000
Reactivity Human
Antibody Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human ACTN4.
Specificity This ACTN4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 192-220 amino acids from the N-terminal region of human ACTN4.
Buffer PBS with 0.09% (W/V) sodium azide
State: Purified
State: Liquid purified Ig
Concentration lot specific
Purification Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Conjugation Unconjugated
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Predicted Protein Size 104.9 kDa
Gene Name actinin alpha 4
Database Link
Background Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This protein is a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and is thought to be involved in metastatic processes. Mutations in the gene encoding this protein have been associated with focal and segmental glomerulosclerosis.
Synonyms Non-muscle alpha actinin 4
Reference Data
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Documents
Resources

file-alt Citations

Shiga toxin promotes podocyte injury in experimental hemolytic uremic syndrome via activation of the alternative pathway of complement
Locatelli, Buelli, Pezzotta et al
J Am Soc Nephrol (2014) 25 (8), 1786-98 DOI: 10.1681/ASN.2013050450
AI Summary: In this study, OriGene’s anti-ILK antibody (Cat# TA324936) was used to detect integrin-linked kinase expression in podocytes, helping to demonstrate the role of ILK signaling in Shiga toxin-induced podocyte injury.
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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