beta 2 Adrenergic Receptor (ADRB2) Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IHC, WB |
|---|---|
| Recommended Dilution | WB:1/2000, IHC-P:1/50-200 |
| Reactivity | Human, Mouse |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide corresponding to 236-264 amino acid residues surrounding S261 of human BAR2. |
| Specificity | This BAR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 236-264 amino acids from human BAR2. |
| Buffer | PBS State: Aff - Purified State: Liquid purified Ig fraction Preservative: 0.09% (W/V) Sodium Azide |
| Concentration | lot specific |
| Purification | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Conjugation | Unconjugated |
| Storage | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Predicted Protein Size | 46.5 kDa |
| Gene Name | adrenoceptor beta 2 |
| Database Link | |
| Background | Beta-2-adrenergic receptor is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. |
| Synonyms | ADRB2, ADRB2R, B2AR, Beta-2 adrenoreceptor |
| Note | Molecular weight: 46459 Da |
| Reference Data | |
Reviews
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Citations
Enhanced humoral immunity in mice lacking CB1 and CB2 receptors (Cnr1-/-/Cnr2-/- mice) is not due to increased splenic noradrenergic neuronal activity
Simkins, Crawford, Goudreau et al
J Neuroimmune Pharmacol (2014) 9 (4), 544-57 DOI: 10.1007/s11481-014-9549-x
Simkins, Crawford, Goudreau et al
J Neuroimmune Pharmacol (2014) 9 (4), 544-57 DOI: 10.1007/s11481-014-9549-x
Cited by 7
AI Summary: In this study, OriGene’s anti-β2 adrenergic receptor antibody (Cat# TA326727) was used to assess β2AR expression on splenic B cells, helping to demonstrate that enhanced humoral immunity in Cnr1(-/-)/Cnr2(-/-) mice is associated with increased β2AR levels rather than increased noradrenergic neuronal activity.
Showing 1-1 of 1 papers.
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