IRE1 (ERN2) (N-term) Rabbit Polyclonal Antibody

SKU AP13752PU-N

IRE1 (ERN2) (N-term) rabbit polyclonal antibody, Purified

Product Data

• Application: WB
• Recommended Dilution:

  Western blot: 1/1000.; Enzyme immunoassay: 1/1000.

• Reactivity: Human, Mouse
• Antibody Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human ERN2.
• Specificity: This antibody reacts to ERN2 / IRE2.
• Buffer: PBS with 0.09% (W/V) sodium azide; State: Purified; State: Liquid purified Ig
• Concentration: lot specific
• Purification: Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.; Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Gene Name: endoplasmic reticulum to nucleus signaling 2
• Database Link:
  Q76MJ5
• Background: ERN2 induces translational repression through 28S ribosomal RNA cleavage in response to endoplasmic reticulum (ER) stress. This pro-apoptotic appears to play no role in the unfolded-protein response, unlike closely related proteins. Overexpression of ERN2 activates both BiP and CHOP expression, and also leads to the development of programmed cell death. It has been suggested that Ern2 plays a role in multiple facets of the ER stress response in mammalian cells.
• Synonyms: Inositol-requiring protein 2, Ire1-beta

Reference Data