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TIM 1 (HAVCR1) (200-300) Rabbit Polyclonal Antibody

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SKU
AP08438PU-N
TIM 1 (HAVCR1) (200-300) rabbit polyclonal antibody, Aff - Purified
Size:
50 ug
Conjugation:
Unconjugated
  $570.00
3 Weeks*
Bulk/Customize

View other "HAVCR1 or NP_001092884.1" antibodies

Specifications
Specifications
Product Data
Application IHC, WB
Recommended Dilution Immunohistochemistry on Paraffin Sections: 2.5 - 5 µg/ml.
Western Blot: 1 - 3 µg/ml.
Reactivity Human, Mouse
Antibody Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen HAVCR1 / KIM-1 antibody was raised against a synthetic peptide (SPLYSYTTDGNDTVT) of human HAVCR1/TIM-1protein were used as immunogen.
This sequence corresponds to amino acids (aa) 248-262 of NP_036338 and aa 84-98 of EAW61615.1. Isoforms of HAVCR1/TIM-1 have been described. For example, NP_036338 is 364 aa and EAW61615.1 is 194 aa. EAW61615.1 is referred to as isoform CRA_a. Percent identity by BLAST analysis: Human, Gorilla (100%); Monkey (93%); Dog (80%).
aa200-300.
Specificity This antibody recognizes Hepatitis A Virus Cellular Receptor 1 (HAVCR1).
Buffer PBS containing 0.05% BSA as stabilizer and 0.05% Sodium Azide as preservative.
State: Aff - Purified
State: Liquid purified Ig fraction.
Concentration lot specific
Purification Protein G Chromatography.
Conjugation Unconjugated
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Gene Name hepatitis A virus cellular receptor 1
Database Link
Background HAVCR1, a 359 A.A Class 1 integral membrane glycoprotein, is used by Hepatitis A virus to infect humans. It consists of a conserved N-terminal Cys-rich region, IgV (Immunoglobulin Variable region like) domain and a TSP-rich mucin domain in the extracellular region followed by a highly conserved tyrosine kinase phosphorylation motif in the cytoplasmic region. HAVCR1 is expressed on terminally differentiated CD4+ Th2 cells and regulates cytokine production. It plays an important role in the regulation of immune responses in the development of asthma and allergic responses. Its expression is critically upregulated in dedifferentiated kidney cells, thus indicating a possible role in regeneration of proximal tubule epithelium in Kidneys. HAVCR1 has shown to be upregulated in renal carcinomas, suggesting its role in tumor progression and metastasis.
Synonyms TIMD-1, TIM1, TIM-1, T cell membrane protein 1, HAVCR-1
Reference Data
Protein Categories CD Markers, Membrane Proteins
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Documents
Resources

file-alt Citations

Brother of regulator of imprinted sites inhibits cisplatin-induced DNA damage in non-small cell lung cancer
Zhang, Song, Li et al
Oncol Lett (2020) 20 (5), 251 DOI: 10.3892/ol.2020.12114
Cited by 10
AI Summary: OriGene products contributed to this study by providing the pBORIS plasmids used for BORIS overexpression and the Flag antibody (cat. no. R1180B) for detecting Flag-tagged proteins, enabling the authors to investigate the role of BORIS in cisplatin resistance in non-small cell lung cancer.
Snippet: Lipofectamine 3000 reagent (Thermo Fisher Scientific, Inc.) was used to transfect pBORIS plasmids purchased from OriGene Technologies Inc Flag antibody (cat. no. R1180B) was purchased from OriGene Technologies, Inc. FITC conjugated rabbit antibody (cat;- Lipofectamine 3000 reagent (Thermo Fisher Scientific, Inc.) was used to transfect pBORIS plasmids purchased from OriGene Technologies Inc Flag antibody (cat. no. R1180B) was purchased from OriGene Technologies, Inc. …
FigureFigureFigure
Showing 1-1 of 1 papers.
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