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SYK pTyr323 Rabbit Polyclonal Antibody

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SKU
AP08041PU-N
SYK pTyr323 rabbit polyclonal antibody, Aff - Purified
Size:
100 ul 50 ul
Conjugation:
Unconjugated
  $430.00
2 Weeks*
Bulk/Customize

View other "SYK or NP_001128524.1" antibodies

Specifications
Specifications
Product Data
Application IF, IHC, WB
Recommended Dilution Western Blot: 1/500-1/1000.
Immunofluorescence: 1/100-1/200.
Immunohistochemistry on Paraffin-Embedded Sections: 1/50-1/100.
Reactivity Human
Antibody Host Rabbit
Clonality Polyclonal
Immunogen The antiserum was produced against synthesized phosphopeptide derived from human syk around the phosphorylation site of Tyrosine 323 (N-P-YP-E- P).
Specificity Antibody AP08041PU detects endogenous levels of Syk only when phosphorylated at Tyrosine 323.
Buffer PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02% Sodium Azide and 50% Glycerol.
State: Aff - Purified
State: Liquid purified Ig fraction.
Concentration lot specific
Purification Affinity Chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Conjugation Unconjugated
Storage Store the antibody (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
Stability Shelf life: One year from despatch.
Shipping Blue Ice
Gene Name spleen tyrosine kinase
Database Link
Background Syk (72 kDa) is a non receptor protein tyrosine kinase that plays an important role in immune receptor signal transduction and is implicated in endothelial cell functions, including cell growth and migration.
SYK is a positive effector of BCR stimulated responses. It couples the B cell antigen receptor (BCR) to the mobilization of calcium ions either through a phosphoinositide 3 kinase dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C gamma dependent pathway, when phosphorylated on Tyr 342 and Tyr 346. Thus the differential phosphorylation of SYK can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ions.
Synonyms Tyrosine-protein kinase SYK, Spleen tyrosine kinase
Reference Data
Protein Categories Cytokines, Enzyme: Kinases, Growth Factors, Immune system diseases, Intracellular Proteins
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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