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PACRG (204-215) Rabbit Polyclonal Antibody

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SKU
AP07237PU-N
PACRG (204-215) rabbit polyclonal antibody, Aff - Purified
Size:
50 ug
Conjugation:
Unconjugated
  $535.00
3 Weeks*
Bulk/Customize

View other "PACRG or NP_001073847.1" antibodies

Specifications
Specifications
Product Data
Application ELISA, IHC, WB
Recommended Dilution ELISA: 1/2000 - 1/10000.
Immunohistochemistry on Paraffin Sections: 2.5 µg/ml.
Western Blot: 1/500 - 1/3000.
Reactivity Chicken, Human, Mouse, Rat, Zebrafish
Antibody Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide from aa 204-215 of human PACRG
Specificity This antibody reacts to amino acids 204-215 of PACRG protein.
Buffer 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 with 0.01% (w/v) Sodium Azide
State: Aff - Purified
State: Liquid purified Ig
Concentration lot specific
Purification Immunoaffinity Chromatography
Conjugation Unconjugated
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Gene Name PARK2 coregulated
Database Link
Background PACRG (also known as Parkin coregulated gene protein and PARK2 coregulated) is a gene located very close to parkin, in reverse orientation on the chromosome. It is thought to be co-transcribed with parkin by a bi-directional promoter between the two genes. PACRG is expressed in all immune tissues, spleen, lymph nodes, thymus, tonsils, leukocyte and bone marrow and is also expressed in heart, brain, skeletal muscle, kidney, lung and pancreas. PACRG is expressed in primary Schwann cells and very weakly by monocyte-derived macrophages, which are the primary host cells of Mycobacterium leprae, the causative agent of leprosy. Splice variants have been described for this protein.
Synonyms Parkin coregulated gene protein, GLUP, PARK2 coregulated gene protein, PARK2CRG
Reference Data
Protein Categories Intracellular Proteins, Membrane Proteins
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Documents
Resources

file-alt Citations

PARK2 and PACRG are commonly downregulated in clear-cell renal cell carcinoma and are associated with aggressive disease and poor clinical outcome
Toma, Wuttig, Kaiser et al
Genes Chromosomes Cancer (2013) 52 (3), 265-73 DOI: 10.1002/gcc.22026
Cited by 31
AI Summary: In this study, OriGene products—specifically the PARK2 (Cat# SC119574) and PACRG (Cat# SC119575) cDNA clones—were used to evaluate gene expression levels, helping to demonstrate that both genes are significantly downregulated in clear-cell renal cell carcinoma and are associated with more aggressive disease and poorer patient outcomes.
Showing 1-1 of 1 papers.
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