C5R1 (C5AR1) Rabbit Polyclonal Antibody
$495.00
7 Weeks*
Specifications
| Product Data | |
| Application | IF, IHC |
|---|---|
| Recommended Dilution | IHC:1/50-200, IF:1/50-200 |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide, corresponding to amino acids 300-350 of Human C5aR. |
| Specificity | This antibody detects endogenous levels of CD88/C5aR protein. (region surrounding Ser334) |
| Buffer | Phosphate buffered saline (PBS), pH~7.2 with 0.02% Sodium Azide and 50% Glycerol. State: Aff - Purified State: Liquid purified Ig fraction (>95% pure by SDS-PAGE) |
| Concentration | 1.0 mg/ml |
| Purification | Affinity-Chromatography using epitope-specific immunogen |
| Conjugation | Unconjugated |
| Storage | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Predicted Protein Size | ~ 45 kDa |
| Gene Name | complement component 5a receptor 1 |
| Database Link | |
| Background | The human anaphylatoxin C5a is a 74 residue glycopeptide which is generated by proteolytic cleavage of the complement factor C5 in the course of complement activation. A variety of biological effects evoked by C5a can be demonstrated, rendering this molecule an important mediartor of inflammation, with granulocytes and macrophages as the main target cells. All cellular responses to C5a are specifically mediated by interactions with the membrane bound C5a receptor, a seven transmembrane GTP binding coupled receptor that belongs to the rhodopsin supergene family. C5a receptor 1 expression has been reported in myeloid blood cells, brain, liver, lung, spleen, heart, kidney, and intestinal tract. ESTs have been isolated from B cell/lung/testis, nerve, and placenta libraries. |
| Synonyms | C5a-R, C5aR, C5AR1, Complement Component 5a Receptor 1 |
| Reference Data | |
| Protein Categories | CD Markers, GPCR, Growth Factors, Intracellular Proteins, Membrane Proteins |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
When trauma hits the heart: Divergent ventricular responses at histological and molecular levels in pigs
Weber, Pavlovic, Brenner et al
Life Sci (2026) 401, 124536 DOI: 10.1016/j.lfs.2026.124536
Weber, Pavlovic, Brenner et al
Life Sci (2026) 401, 124536 DOI: 10.1016/j.lfs.2026.124536
AI Summary: OriGene contributed to this study by providing the rabbit polyclonal antibody against C5aR1 (#AP06508PU-N), which was used for immunohistochemical analysis of cardiac tissue to assess trauma-induced changes in the ventricles.
Snippet: Formalin-fixed and paraffin embedded left and right ventricles were used for immunohistochemistry. C5aR1 was stained with rabbit polyclonal antibody (ORIGENE, #AP06508PU-N, Herford, Germany), Cx43 with rabbit anti-pig Cx43 antibody (Cell Signaling Technology, #3512S, Danvers, MA, USA). Nitrotyrosine staining was performed using rabbit anti
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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