Caspase 5 (CASP5) Rabbit Polyclonal Antibody
$595.00
5 Days*
Specifications
| Product Data | |
| Application | IF, WB |
|---|---|
| Recommended Dilution | Western blot: 1.0 µg/ml - 2.0 µg/ml; detects a band of approximately 48 kDa in Ramos cell lysates. (Predicted precursor MWT 47.8kDa). Immuncytochemistry. |
| Reactivity | Human |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | A 14 amino acid peptide from the centre of human Caspase-5. |
| Specificity | This antibody recognises an epitope located within the internal region of human Caspase-5, a 47kDa cysteine protease, otherwise known as ICH-3. |
| Buffer | Phosphate buffered saline containing 0.02% Sodium Azide State: Purified State: Liquid purified Ig |
| Concentration | lot specific |
| Purification | Affinity chromatography |
| Conjugation | Unconjugated |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Gene Name | caspase 5 |
| Database Link | |
| Background | Caspase-5 has been shown to be expressed at higher levels in the colon, lung, spleen, small intestine and by peripheral blood lymphocytes. Caspase-5 is a member of a growing number of inflammatory caspases belonging to the Caspase-1 (ICE-type) subfamily, which require proteolytic processing of their inactive precursor into smaller active subunits. Unlike Caspase-1, Caspase-5 is not directly responsible for the activation of IL-1Beta from the pro-IL-1Beta precursor, but the presence of Caspase-5 does appear to enhance the processing of IL-1Beta. The in vivo expression of Caspase-5 is elevated by Lipopolysaccharide (LPS) and gene expression is also increased by Interferon gamma (IFNg). In vitro studies have shown cleavage of Caspase-5 by the serine protease Granzyme B, which plays a major role in Cytotoxic T lymphocyte (CTL)-induced apoptosis (1). |
| Synonyms | CASP-5, CASP5, ICH3, ICH-3 protease, TY protease, ICE(rel)-III |
| Reference Data | |
| Protein Categories | Enzyme: Peptidases, Intracellular Proteins |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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